Literature DB >> 1556122

Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure.

M Mörgelin1, D Heinegård, J Engel, M Paulsson.   

Abstract

Cartilage oligomeric matrix protein was isolated in the native state from the Swarm rat chondrosarcoma. A crucial step was its selective extraction with EDTA-containing buffer. The purified protein was subjected to electron microscopy using rotary shadowing and negative stain. The images allowed the construction of a structural model. The bouquet-like protein consists of five 28-nm-long arms containing a peripheral globular domain, a flexible strand, and a central assembly domain, where the five arms meet in a cylindrical structure.

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Year:  1992        PMID： 1556122

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  37 in total

1.  Degradation of extracellular matrix molecules in interleukin-1α treated bovine nasal cartilage.

Authors:  Behnaz Shohani; Mahmoud Orazizadeh; Mahmoud Hashemitabar; Dick Heinegard
Journal:  Iran Biomed J       Date:  2010-10

2.  Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes.

Authors:  C Vingsbo; P Sahlstrand; J G Brun; R Jonsson; T Saxne; R Holmdahl
Journal:  Am J Pathol       Date:  1996-11       Impact factor: 4.307

3.  Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes.

Authors:  Anna C Berardi; Francesco Oliva; Martina Berardocco; Marina la Rovere; Patrizia Accorsi; Nicola Maffulli
Journal:  Muscles Ligaments Tendons J       Date:  2014-11-17

4.  Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein.

Authors:  Dominik R Haudenschild; Eunmee Hong; Jasper H N Yik; Brett Chromy; Matthias Mörgelin; Kaylene D Snow; Chitrangada Acharya; Yoshikazu Takada; Paul E Di Cesare
Journal:  J Biol Chem       Date:  2011-09-22       Impact factor: 5.157

5.  Extracellular Distribution of Collagen II and Perifibrillar Adapter Proteins in Healthy and Osteoarthritic Human Knee Joint Cartilage.

Authors:  Sara Firner; Frank Zaucke; Joern Michael; Jens Dargel; Karl-Heinz Schiwy-Bochat; Juliane Heilig; Markus Alexander Rothschild; Peer Eysel; Gert-Peter Brüggemann; Anja Niehoff
Journal:  J Histochem Cytochem       Date:  2017-08-28       Impact factor: 2.479

6.  The distribution patterns of COMP and matrilin-3 in septal, alar and triangular cartilages of the human nose.

Authors:  Paul Severin Wiggenhauser; Silke Schwarz; Nicole Rotter
Journal:  Histochem Cell Biol       Date:  2018-05-02       Impact factor: 4.304

7.  Microarray analysis identifies COMP as the most differentially regulated transcript throughout in vitro follicle growth.

Authors:  Robin M Skory; Beatriz Peñalver Bernabé; Eugene Galdones; Linda J Broadbelt; Lonnie D Shea; Teresa K Woodruff
Journal:  Mol Reprod Dev       Date:  2013-01-30       Impact factor: 2.609

8.  Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats.

Authors:  S Carlsén; A S Hansson; H Olsson; D Heinegård; R Holmdahl
Journal:  Clin Exp Immunol       Date:  1998-12       Impact factor: 4.330

9.  Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: a one year prospective study.

Authors:  T Conrozier; T Saxne; C S Fan; P Mathieu; A M Tron; D Heinegård; E Vignon
Journal:  Ann Rheum Dis       Date:  1998-09       Impact factor: 19.103

10.  Altered synthesis of cartilage-specific proteoglycans by mutant human cartilage oligomeric matrix protein.

Authors:  Yoon Hae Kwak; Jae Young Roh; Ki Seok Lee; Hui Wan Park; Hyun Woo Kim
Journal:  Clin Orthop Surg       Date:  2009-11-25
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