Literature DB >> 15560978

Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs.

Diana Felnerova1, Jean-François Viret, Reinhard Glück, Christian Moser.   

Abstract

Lipid-based vesicles are a very promising approach to treat diseases such as cancer, chronic infections and auto-immunity. Modern drug encapsulation methods allow efficient packing of therapeutic substances inside liposomes, thereby reducing the systemic toxicity of the drugs. Specific targeting can enhance the therapeutic effect of the drugs through their accumulation at the diseased site. In the vaccine field, the integration of functional viral envelope proteins into liposomes has led to an antigen carrier and delivery system termed a virosome, a clinically proven vaccine platform for subunit vaccines with an excellent immunogenicity and tolerability profile.

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Year:  2004        PMID： 15560978     DOI： 10.1016/j.copbio.2004.10.005

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  48 in total

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Authors:  David J Chen; Nikolaus Osterrieder; Stephan M Metzger; Elizabeth Buckles; Anne M Doody; Matthew P DeLisa; David Putnam
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Authors:  Yu Zhang; Shuibin Lin; Xiang-Yang Wang; Guizhi Zhu
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2019-06-06

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Journal:  Vaccine       Date:  2014-08-08       Impact factor: 3.641

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Journal:  Daru       Date:  2019-08-02       Impact factor: 3.117

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Authors:  Adam S Lauring; Jeremy O Jones; Raul Andino
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