Literature DB >> 15557762

DNA microarray analysis of pancreatic malignancies.

Regine Brandt1, Robert Grützmann, Andrea Bauer, Ralf Jesnowski, Jörg Ringel, Matthias Löhr, Christian Pilarsky, Jörg D Hoheisel.   

Abstract

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment are needed. Recent advances in human genome research and high-throughput molecular technologies make it possible to cope with the molecular complexity of malignant tumors. With DNA array technology, mRNA expression levels of thousand of genes can be measured simultaneously in a single assay. As several studies using microarrays in PDAC have already been published, this review attempts to compare the published data and therefore to validate the results. In addition, the applied techniques are discussed in the context of pancreatic malignancies. Copyright 2004 S. Karger AG, Basel and IAP.

Entities:  

Mesh：

Year:  2004        PMID： 15557762     DOI： 10.1159/000082241

Source DB:  PubMed          Journal:  Pancreatology        ISSN： 1424-3903            Impact factor:   3.996


  17 in total

Review 1.  [Proteome analysis--basis for individualized pancreatic carcinoma therapy?].

Authors:  J M Löhr; R Faissner; P Findeisen; M Neumaier
Journal:  Internist (Berl)       Date:  2006-06       Impact factor: 0.743

2.  Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers.

Authors:  Randy S Haun; Charles M Quick; Eric R Siegel; Ilangovan Raju; Samuel G Mackintosh; Alan J Tackett
Journal:  Cancer Biol Ther       Date:  2015-07-15       Impact factor: 4.742

3.  Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples.

Authors:  Henrik Laurell; Michele Bouisson; Philippe Berthelemy; Philippe Rochaix; Sebastien Dejean; Philippe Besse; Christiane Susini; Lucien Pradayrol; Nicole Vaysse; Louis Buscail
Journal:  World J Gastroenterol       Date:  2006-06-07       Impact factor: 5.742

4.  Genes and proteins differentially expressed during in vitro malignant transformation of bovine pancreatic duct cells.

Authors:  R Jesnowski; Dmitri Zubakov; Ralf Faissner; Jörg Ringel; Jörg D Hoheisel; Ralf Lösel; Martina Schnölzer; Matthias Löhr
Journal:  Neoplasia       Date:  2007-02       Impact factor: 5.715

5.  A preliminary result of three-dimensional microarray technology to gene analysis with endoscopic ultrasound-guided fine-needle aspiration specimens and pancreatic juices.

Authors:  Koji Nonogaki; Akihiro Itoh; Hiroki Kawashima; Eizaburo Ohno; Takuya Ishikawa; Hiroshi Matsubara; Yuya Itoh; Yosuke Nakamura; Masanao Nakamura; Ryoji Miyahara; Naoki Ohmiya; Masatoshi Ishigami; Yoshiaki Katano; Hidemi Goto; Yoshiki Hirooka
Journal:  J Exp Clin Cancer Res       Date:  2010-04-25

6.  A novel HMM-based method for detecting enriched transcription factor binding sites reveals RUNX3 as a potential target in pancreatic cancer biology.

Authors:  Liron Levkovitz; Nir Yosef; Marvin C Gershengorn; Eytan Ruppin; Roded Sharan; Yoram Oron
Journal:  PLoS One       Date:  2010-12-22       Impact factor: 3.240

Review 7.  Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature.

Authors:  Martin Loos; Frank Bergmann; Andrea Bauer; Jörg D Hoheisel; Irene Esposito; Jörg Kleeff; Peter Schirmacher; Markus W Büchler; Günter Klöppel; Helmut Friess
Journal:  Virchows Arch       Date:  2007-04-24       Impact factor: 4.064

8.  Identifying Biomarkers and Drug Targets Using Systems Biology Approaches for Pancreatic Cancer.

Authors:  Yi Tan; Lucio Miele; Fazlul H Sarkar; Zhiwei Wang
Journal:  Pancreat Disord Ther       Date:  2012-12-06

Review 9.  N-terminal RASSF family: RASSF7-RASSF10.

Authors:  Nicholas Underhill-Day; Victoria Hill; Farida Latif
Journal:  Epigenetics       Date:  2011-03-01       Impact factor: 4.528

10.  Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung.

Authors:  Tatyana Kalinina; Cenap Güngör; Sabrina Thieltges; Maren Möller-Krull; Eva Maria Murga Penas; Daniel Wicklein; Thomas Streichert; Udo Schumacher; Viacheslav Kalinin; Ronald Simon; Benjamin Otto; Judith Dierlamm; Heidi Schwarzenbach; Katharina E Effenberger; Maximilian Bockhorn; Jakob R Izbicki; Emre F Yekebas
Journal:  BMC Cancer       Date:  2010-06-16       Impact factor: 4.430
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