Literature DB >> 15557740

Effects of endocytosis inhibitory drugs on rubella virus entry into VeroE6 cells.

Sun-Ho Kee1, Eun-Jin Cho, Jin-Won Song, Kwang Sook Park, Luck Ju Baek, Ki-Joon Song.   

Abstract

It has been suggested that infectious entry of rubella virus (RV) is conducted by receptor mediated endocytosis. To explore the cellular entry mechanism of RV, inhibitory effects of drugs affecting various endocytic pathways on RV entry into VeroE6 cells were analyzed. Results showed that RV infectious entry into VeroE6 cells is mediated by clathrin-dependent endocytosis and not by caveolae-mediated endocytosis. Moreover, chemical inhibition of macropinocytosis such as treatments of amiloride, actin and microtubule-disrupting drug significantly reduced RV infection. Considering that macropinocytosis is inducible endocytosis by cellular stimulations, clathrin-mediated endocytosis is likely to be a major route of RV infectious entry.

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Year:  2004        PMID： 15557740     DOI： 10.1111/j.1348-0421.2004.tb03614.x

Source DB:  PubMed          Journal:  Microbiol Immunol        ISSN： 0385-5600            Impact factor:   1.955


  23 in total

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