Literature DB >> 15557667

Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic.

Matthew J Burton1, Robin L Bailey, David Jeffries, David C W Mabey, Martin J Holland.   

Abstract

The role of immunity in blinding trachoma is unclear. Conjunctival gene expression was measured in a population where trachoma is endemic. Proinflammatory (tumor necrosis factor alpha and interleukin-1beta [IL-1beta]), anti-inflammatory (IL-10), and fibrogenic (matrix metalloprotease 9) gene expression was increased in active trachoma. Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present.

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Year:  2004        PMID： 15557667      PMCID： PMC529133          DOI： 10.1128/IAI.72.12.7352-7356.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  43 in total

Review 1.  Anti-inflammatory cytokines.

Authors:  S M Opal; V A DePalo
Journal:  Chest       Date:  2000-04       Impact factor: 9.410

Review 2.  Role of transforming growth factor beta in human disease.

Authors:  G C Blobe; W P Schiemann; H F Lodish
Journal:  N Engl J Med       Date:  2000-05-04       Impact factor: 91.245

3.  Polymorphisms in candidate genes and risk of scarring trachoma in a Chlamydia trachomatis--endemic population.

Authors:  N Mozzato-Chamay; O S Mahdi; O Jallow; D C Mabey; R L Bailey; D J Conway
Journal:  J Infect Dis       Date:  2000-10-09       Impact factor: 5.226

4.  Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis.

Authors:  M Kolb; P J Margetts; D C Anthony; F Pitossi; J Gauldie
Journal:  J Clin Invest       Date:  2001-06       Impact factor: 14.808

5.  Expression of gelatinase B in trachomatous conjunctivitis.

Authors:  A M El-Asrar; K Geboes; S A Al-Kharashi; A A Al-Mosallam; L Missotten; L Paemen; G Opdenakker
Journal:  Br J Ophthalmol       Date:  2000-01       Impact factor: 4.638

6.  Development of a quantitative gene expression assay for Chlamydia trachomatis identified temporal expression of sigma factors.

Authors:  S A Mathews; K M Volp; P Timms
Journal:  FEBS Lett       Date:  1999-09-24       Impact factor: 4.124

7.  Regulation of collagenase, stromelysin, and gelatinase B in human conjunctival and conjunctivochalasis fibroblasts by interleukin-1beta and tumor necrosis factor-alpha.

Authors:  D Meller; D Q Li; S C Tseng
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-09       Impact factor: 4.799

8.  Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4(+) T cells but not CD8(+) T cells.

Authors:  S G Morrison; H Su; H D Caldwell; R P Morrison
Journal:  Infect Immun       Date:  2000-12       Impact factor: 3.441

9.  Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro.

Authors:  D A Siwik; D L Chang; W S Colucci
Journal:  Circ Res       Date:  2000-06-23       Impact factor: 17.367

10.  In situ analysis of the evolution of the primary immune response in murine Chlamydia trachomatis genital tract infection.

Authors:  S G Morrison; R P Morrison
Journal:  Infect Immun       Date:  2000-05       Impact factor: 3.441
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  40 in total

1.  Setting Sights on Chlamydia Immunity's Central Paradigm: Can We Hit a Moving Target?

Authors:  Rodolfo D Vicetti Miguel; Nirk E Quispe Calla; Thomas L Cherpes
Journal:  Infect Immun       Date:  2017-06-20       Impact factor: 3.441

2.  Active trachoma is associated with increased conjunctival expression of IL17A and profibrotic cytokines.

Authors:  Matthew J Burton; Athumani Ramadhani; Helen A Weiss; Victor Hu; Patrick Massae; Sarah E Burr; Wahida Shangali; Martin J Holland; David C W Mabey; Robin L Bailey
Journal:  Infect Immun       Date:  2011-09-12       Impact factor: 3.441

3.  Conjunctival expression of matrix metalloproteinase and proinflammatory cytokine genes after trichiasis surgery.

Authors:  Matthew J Burton; Robin L Bailey; David Jeffries; Saul N Rajak; Richard A Adegbola; Ansumana Sillah; David C W Mabey; Martin J Holland
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-03-17       Impact factor: 4.799

Review 4.  The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on.

Authors:  J K Dart
Journal:  Eye (Lond)       Date:  2017-01-20       Impact factor: 3.775

5.  Role of matrix metalloproteinase-7 in the modulation of a Chlamydia trachomatis infection.

Authors:  Sukumar Pal; Amy P Schmidt; Ellena M Peterson; Carole L Wilson; Luis M de la Maza
Journal:  Immunology       Date:  2006-02       Impact factor: 7.397

6.  Conjunctival transcriptome in scarring trachoma.

Authors:  Matthew J Burton; Saul N Rajak; Julien Bauer; Helen A Weiss; Sonda B Tolbert; Alice Shoo; Esmail Habtamu; Alphaxard Manjurano; Paul M Emerson; David C W Mabey; Martin J Holland; Robin L Bailey
Journal:  Infect Immun       Date:  2010-10-11       Impact factor: 3.441

7.  Profound and sustained reduction in Chlamydia trachomatis in The Gambia: a five-year longitudinal study of trachoma endemic communities.

Authors:  Matthew J Burton; Martin J Holland; Pateh Makalo; Esther A N Aryee; Ansumana Sillah; Sandra Cohuet; Angels Natividad; Neal D E Alexander; David C W Mabey; Robin L Bailey
Journal:  PLoS Negl Trop Dis       Date:  2010-10-05

8.  Doxycycline prevents matrix remodeling and contraction by trichiasis-derived conjunctival fibroblasts.

Authors:  He Li; Daniel G Ezra; Matthew J Burton; Maryse Bailly
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-07-12       Impact factor: 4.799

Review 9.  The global burden of trachoma: a review.

Authors:  Matthew J Burton; David C W Mabey
Journal:  PLoS Negl Trop Dis       Date:  2009-10-27

10.  Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.

Authors:  Angels Natividad; Jeremy Hull; Gaia Luoni; Martin Holland; Kirk Rockett; Hassan Joof; Matthew Burton; David Mabey; Dominic Kwiatkowski; Robin Bailey
Journal:  BMC Med Genet       Date:  2009-12-16       Impact factor: 2.103
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