| Literature DB >> 15556762 |
Adam R Yeager1, Nathaniel S Finney.
Abstract
Chitin synthase (CS) is essential for fungal cell wall biosynthesis and is an attractive medicinal target. Expanded results from our efforts to develop mechanism based inhibitors of CS are presented here. Specifically, we describe uridine dimers linked by tartrate amides as potential pyrophosphate mimics.Entities:
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Year: 2004 PMID： 15556762 DOI： 10.1016/j.bmc.2004.09.027
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641