| Literature DB >> 15556758 |
Jinhua Wang1, Bryan Elchert, Yu Hui, Jon Y Takemoto, Mekki Bensaci, John Wennergren, Huiwen Chang, Ravi Rai, Cheng-Wei Tom Chang.
Abstract
The synthesis of a library of trehalose-based compounds has been accomplished, and their activities against Mycobacterium smegmatis have been determined. A preliminary structure-activity relationship (SAR) is reported. Despite not having a potent lead, one of the trehalose derivatives displays strong activity when applied with isoniazid (INH), which is known to have low sterilizing activity. The bacteriocidal nature of our compounds against Mycobacterium may be significant for the development of new therapies against tuberculosis.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15556758 DOI： 10.1016/j.bmc.2004.09.033
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641