Literature DB >> 1555657

The X-ray structure of a tetrapeptide bound to the active site of human cyclophilin A.

J Kallen1, M D Walkinshaw.   

Abstract

Human cyclophilin A (165 residues) has peptidyl-prolyl cis-trans isomerase activity. Here we report a high-resolution three-dimensional X-ray structure of a substrate, ac-Ala-Ala-Pro-Ala-amc (ac, acetyl; amc, amidomethylcoumarin) bound to the active-site of cyclophilin. The structure consisting of a dimer of complexes and 135 water molecules was refined to a crystallographic R-factor of 17.7% for all data in the range 8 A-2.3 A.

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Year:  1992        PMID： 1555657     DOI： 10.1016/0014-5793(92)80865-e

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

1.  Structural consequences of cyclophilin A binding on maturational refolding in human immunodeficiency virus type 1 capsid protein.

Authors:  L Dietrich; L S Ehrlich; T J LaGrassa; D Ebbets-Reed; C Carter
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

2.  A molecular dynamics study of Cyclophilin A free and in complex with the Ala-Pro dipeptide.

Authors:  Pekka Mark; Lennart Nilsson
Journal:  Eur Biophys J       Date:  2007-01-16       Impact factor: 1.733

3.  Kinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomerase.

Authors:  Ana Y Mercedes-Camacho; Ashley B Mullins; Matthew D Mason; Guoyan G Xu; Brendan J Mahoney; Xingsheng Wang; Jeffrey W Peng; Felicia A Etzkorn
Journal:  Biochemistry       Date:  2013-10-24       Impact factor: 3.162

4.  Crystal structure of cyclophilin A complexed with substrate Ala-Pro suggests a solvent-assisted mechanism of cis-trans isomerization.

Authors:  H Ke; D Mayrose; W Cao
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

Review 5.  A novel model of cholesterol efflux from lipid-loaded cells.

Authors:  Di-xian Luo; De-liang Cao; Yan Xiong; Xu-hong Peng; Duan-fang Liao
Journal:  Acta Pharmacol Sin       Date:  2010-09-13       Impact factor: 6.150

6.  Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization.

Authors:  J Colgan; H E Yuan; E K Franke; J Luban
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

7.  A cyclophilin from the polycentric anaerobic rumen fungus Orpinomyces sp. strain PC-2 is highly homologous to vertebrate cyclophilin B.

Authors:  H Chen; X L Li; L G Ljungdahl
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

8.  Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae.

Authors:  K Dolinski; C Scholz; R S Muir; S Rospert; F X Schmid; M E Cardenas; J Heitman
Journal:  Mol Biol Cell       Date:  1997-11       Impact factor: 4.138

9.  Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis.

Authors:  Yanmin Li; Nicholas Johnson; Michela Capano; Mina Edwards; Martin Crompton
Journal:  Biochem J       Date:  2004-10-01       Impact factor: 3.857

10.  Crystal structure of the cyclophilin-like domain from the parasitic nematode Brugia malayi.

Authors:  V Mikol; D Ma; C K Carlow
Journal:  Protein Sci       Date:  1998-06       Impact factor: 6.725
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