Literature DB >> 1555653

Immunocharacterization of delta- and zeta-isoenzymes of protein kinase C in rat renal mesangial cells.

A Huwiler1, D Fabbro, S Stabel, J Pfeilschifter.   

Abstract

The isoforms of protein kinase C (PKC) present in rat mesangial cells were identified by immunoblot analysis with antibody raised against isotype-specific peptides. In addition to the previously observed alpha- and epsilon-subspecies, mesangial cells also express the delta- and zeta-isoenzymes of PKC. On exposure to phorbol 12,13-dibutyrate (PDB) a complete depletion of PKC-delta is observed within 8 h. Removal of PDB results in a recovery of PKC-delta. In contrast, PKC-zeta is unaffected by addition or removal of PDB.

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Year:  1992        PMID： 1555653     DOI： 10.1016/0014-5793(92)80858-e

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.

Authors:  A Huwiler; J Brunner; R Hummel; M Vervoordeldonk; S Stabel; H van den Bosch; J Pfeilschifter
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

Review 2.  Protein kinase C isoenzymes: divergence in signal transduction?

Authors:  H Hug; T F Sarre
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

3.  Translocation of protein kinase C alpha and zeta in rat glomerular mesangial cells cultured under high glucose conditions.

Authors:  R Kikkawa; M Haneda; T Uzu; D Koya; T Sugimoto; Y Shigeta
Journal:  Diabetologia       Date:  1994-08       Impact factor: 10.122

4.  Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.

Authors:  D Kunz; G Walker; W Eberhardt; U K Messmer; A Huwiler; J Pfeilschifter
Journal:  J Clin Invest       Date:  1997-12-01       Impact factor: 14.808

5.  Effect of phorbol 12, 13-dibutyrate on ligand binding, enzyme activity and translocation of protein kinase C isoforms in the alpha T3-1 gonadotrope-derived cell line.

Authors:  M S Johnson; J Simpson; R Mitchell
Journal:  Mol Cell Biochem       Date:  1996-12-06       Impact factor: 3.396

6.  Transcriptional activation of low density lipoprotein receptor gene by angiotensin-converting enzyme inhibitors and Ca(2+)-channel blockers involves protein kinase C isoforms.

Authors:  L H Block; R Keul; M Crabos; R Ziesche; M Roth
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

7.  Different roles of protein kinase C-beta and -delta in arachidonic acid cascade, superoxide formation and phosphoinositide hydrolysis.

Authors:  J Duyster; H Schwende; E Fitzke; H Hidaka; P Dieter
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857

8.  Modulatory role of platelet-derived growth factor on cytokine-induced nerve growth factor synthesis in rat glomerular mesangial cells.

Authors:  K M Plüss; J Pfeilschifter; H Mühl; A Huwiler; C Boeckh; U Otten
Journal:  Biochem J       Date:  1995-12-15       Impact factor: 3.857

9.  Stimulation by extracellular ATP and UTP of the mitogen-activated protein kinase cascade and proliferation of rat renal mesangial cells.

Authors:  A Huwiler; J Pfeilschifter
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739

10.  Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-epsilon in rat renal mesangial cells.

Authors:  J Pfeilschifter; C Merriweather
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739
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