| Literature DB >> 15555540 |
Rahul Mittal1, Sanjay Chhibber, Saroj Sharma, Kusum Harjai.
Abstract
This study analyzed macrophage inflammatory protein-2 (MIP-2) production and neutrophil recruitment in urinary tract in response to Pseudomonas aeruginosa in an ascending model of urinary tract infection (UTI) in mice. Both planktonic and biofilm cells of P. aeruginosa were used for inducing UTI in mice. MIP-2 levels determined in urine, bladder and kidney showed maximum MIP-2 production 6 h postinfection, which correlated with neutrophil recruitment. Biofilm cells showed significantly more MIP-2 production and neutrophil recruitment. However, no correlation between bacterial numbers and neutrophil recruitment was observed in urine and kidney tissue. The role of MIP-2 and neutrophils in relation to the persistence of P. aeruginosa in the urinary tract of mice is discussed.Entities:
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Year: 2004 PMID： 15555540 DOI： 10.1016/j.micinf.2004.08.008
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700