Cross-regulation of Wnt signaling and cell adhesion.

The complex cross-regulation between Wnt signaling, cell-cell adhesion, and cell-matrix adhesion has revealed a number of regulatory components important in development and cancer progression. In the following, we would like to highlight and summarize some of the steps where pathways converge or diverge in regulating Wnt activity, matrix-induced pathways, and cell adhesion. We would like to focus on the involvement of heparan sulfate proteoglycan-rich proteins (HSPGs), integrin-mediated outside-in signaling, and cadherin-mediated cell-cell adhesion on Wnt pathways and the transcriptional regulation of extracellular matrix components and cell adhesion molecules by Wnt signaling.