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Literature DB >> 1555245

Production of nitrite by neonatal rat microglial cells/brain macrophages.

J Zielasek¹, M Tausch, K V Toyka, H P Hartung.

Abstract

Microglial cells/brain macrophages from neonatal rats were examined for their capacity to generate nitrite, a product of the NO pathway. Upon incubation with bacterial lipopolysaccharide (LPS) or rat interferon-gamma (IFN-gamma), cells from the microglia-enriched fraction released measurable amounts of nitrite into the supernatant within 24-48 hr. The production of nitrite was dependent on the cell number and the dose of IFN-gamma and LPS. It could be inhibited by NG-monomethylarginine. We conclude that activated microglial cells can secrete nitrite. Stimulation of the NO pathway in microglial cells may be relevant to the pathogenesis of inflammatory and autoimmune demyelinating diseases of the brain.

Entities: Chemical Disease Gene Species

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Year: 1992 PMID： 1555245 DOI： 10.1016/0008-8749(92)90131-8

Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868

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Cited

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Production of nitrite by neonatal rat microglial cells/brain macrophages.

1. Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development.

2. Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool.

3. A novel cell line from spontaneously immortalized murine microglia.

4. Prostaglandin E2 and 4-aminopyridine prevent the lipopolysaccharide-induced outwardly rectifying potassium current and interleukin-1beta production in cultured rat microglia.

Review 5. Intrinsic regulation of brain inflammatory responses.

6. Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.

7. Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis.

8. Neurodegeneration and glia response in rat hippocampus following nitro-L-arginine methyl ester (L-NAME).

Review 9. Theiler's virus infection: a model for multiple sclerosis.

10. Biomolecular events involved in anticryptococcal resistance in the brain.