Literature DB >> 15551218

Longitudinal analysis of nef/long terminal repeat-deleted HIV-1 in blood and cerebrospinal fluid of a long-term survivor who developed HIV-associated dementia.

Melissa Churchill1, Jasminka Sterjovski, Lachlan Gray, Daniel Cowley, Catherine Chatfield, Jennifer Learmont, John S Sullivan, Suzanne M Crowe, John Mills, Bruce J Brew, Steven L Wesselingh, Dale A McPhee, Paul R Gorry.   

Abstract

We studied the evolution and compartmentalization of nef/long terminal repeat (nef/LTR)-deleted human immunodeficiency virus type 1 (HIV-1) from a long-term survivor who developed HIV-associated dementia (HIVD). Analysis of sequential blood-derived HIV-1 isolated before and during HIVD revealed a persistent R5X4 phenotype and a progressive loss of nef/LTR sequence; in contrast, HIV-1 present in cerebrospinal fluid during HIVD had an R5 phenotype, distinct nef/LTR sequence of unique deletions and additional nuclear factor- kappa B sites and specificity factor-1 sites, and enhanced transcriptional activity, compared with the blood-derived isolates. Thus, nef/LTR-deleted HIV-1 strains may undergo compartmentalized evolution in long-term survivors and cause neurologic disease.

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Year:  2004        PMID： 15551218     DOI： 10.1086/425585

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  18 in total

1.  Transcriptional activity of blood-and cerebrospinal fluid-derived nef/long-terminal repeat sequences isolated from a slow progressor infected with nef-deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia.

Authors:  Melissa J Churchill; Anna Figueiredo; Daniel Cowley; Lachlan Gray; Damian Fj Purcell; John S Sullivan; Dale A McPhee; Steven L Wesselingh; Bruce J Brew; Paul R Gorry
Journal:  J Neurovirol       Date:  2006-06       Impact factor: 2.643

2.  Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.

Authors:  Paul R Gorry; Rebecca L Dunfee; Megan E Mefford; Kevin Kunstman; Tom Morgan; John P Moore; John R Mascola; Kristin Agopian; Geoffrey H Holm; Andrew Mehle; Joann Taylor; Michael Farzan; Hui Wang; Philip Ellery; Samantha J Willey; Paul R Clapham; Steven M Wolinsky; Suzanne M Crowe; Dana Gabuzda
Journal:  Virology       Date:  2007-01-18       Impact factor: 3.616

3.  Longitudinal analysis of human immunodeficiency virus type 1 nef/long terminal repeat sequences in a cohort of long-term survivors infected from a single source.

Authors:  Melissa J Churchill; David I Rhodes; Jennifer C Learmont; John S Sullivan; Steven L Wesselingh; Ian R C Cooke; Nicholas J Deacon; Paul R Gorry
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

Review 4.  Animal models for depression associated with HIV-1 infection.

Authors:  Isabella Cristina Gomes Barreto; Patricia Viegas; Edward B Ziff; Elisabete Castelon Konkiewitz
Journal:  J Neuroimmune Pharmacol       Date:  2013-12-12       Impact factor: 4.147

5.  CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates.

Authors:  Lachlan R Gray; Dana Gabuzda; Daniel Cowley; Anne Ellett; Lisa Chiavaroli; Steven L Wesselingh; Melissa J Churchill; Paul R Gorry
Journal:  J Neurovirol       Date:  2010-11-30       Impact factor: 2.643

Review 6.  Morphine and rapid disease progression in nonhuman primate model of AIDS: inverse correlation between disease progression and virus evolution.

Authors:  Vanessa Rivera-Amill; Peter S Silverstein; Richard J Noel; Santosh Kumar; Anil Kumar
Journal:  J Neuroimmune Pharmacol       Date:  2009-12-16       Impact factor: 4.147

7.  Macrophages sustain HIV replication in vivo independently of T cells.

Authors:  Jenna B Honeycutt; Angela Wahl; Caroline Baker; Rae Ann Spagnuolo; John Foster; Oksana Zakharova; Stephen Wietgrefe; Carolina Caro-Vegas; Victoria Madden; Garrett Sharpe; Ashley T Haase; Joseph J Eron; J Victor Garcia
Journal:  J Clin Invest       Date:  2016-03-07       Impact factor: 14.808

8.  Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation.

Authors:  Dohun Pyeon; Khalid Amine Timani; Fahad Gulraiz; Johnny J He; In-Woo Park
Journal:  Virus Res       Date:  2016-07-25       Impact factor: 3.303

9.  Viral phenotypes and antibody responses in long-term survivors infected with attenuated human immunodeficiency virus type 1 containing deletions in the nef and long terminal repeat regions.

Authors:  Erin E Verity; Dimitra Zotos; Kim Wilson; Catherine Chatfield; Victoria A Lawson; Dominic E Dwyer; Anthony Cunningham; Jennifer Learmont; Wayne Dyer; John Sullivan; Melissa Churchill; Steven L Wesselingh; Dana Gabuzda; Paul R Gorry; Dale A McPhee
Journal:  J Virol       Date:  2007-06-13       Impact factor: 5.103

10.  Reduced basal transcriptional activity of central nervous system-derived HIV type 1 long terminal repeats.

Authors:  Lachlan R Gray; Daniel Cowley; Emma Crespan; Casey Welsh; Charlene Mackenzie; Steve L Wesselingh; Paul R Gorry; Melissa J Churchill
Journal:  AIDS Res Hum Retroviruses       Date:  2012-09-25       Impact factor: 2.205
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