Vanderson Rocha1, Guillermo Sanz, Eliane Gluckman. 1. Eurocord Office, Bone Marrow Transplant, Hematology Department, Hôpital Saint Louis, Paris, France. vanderson.rocha@sls.ap-hop-paris.fr
Abstract
PURPOSE OF REVIEW: Familiar and unrelated umbilical cord blood is an appealing alternative source of hematopoietic stem cells patients undergoing transplantation for a wide variety of diseases. In the unrelated donor transplant setting, shorter time to transplant, which is particularly relevant to patients requiring urgent transplantation, and tolerance of 1-2 human leukocyte antigen mismatch, which increases the chance of finding a suitable donor, are evident advantages over bone marrow transplantation. The speed of engraftment is slower after cord blood transplantation but it is counterbalanced by a lower incidence of severe graft-versus-host disease. Cell dose and human leukocyte antigen are major factors influencing outcome after umbilical cord blood transplantation. RECENT FINDINGS: Unrelated donor cord blood transplantation is considered an acceptable option to bone marrow for pediatric transplantation, and recent data in adults point the same way. SUMMARY: This review describes the recent clinical results of cord blood transplantation and discusses developing research strategies aimed at optimizing this kind of transplantation.
PURPOSE OF REVIEW: Familiar and unrelated umbilical cord blood is an appealing alternative source of hematopoietic stem cells patients undergoing transplantation for a wide variety of diseases. In the unrelated donor transplant setting, shorter time to transplant, which is particularly relevant to patients requiring urgent transplantation, and tolerance of 1-2 human leukocyte antigen mismatch, which increases the chance of finding a suitable donor, are evident advantages over bone marrow transplantation. The speed of engraftment is slower after cord blood transplantation but it is counterbalanced by a lower incidence of severe graft-versus-host disease. Cell dose and human leukocyte antigen are major factors influencing outcome after umbilical cord blood transplantation. RECENT FINDINGS: Unrelated donor cord blood transplantation is considered an acceptable option to bone marrow for pediatric transplantation, and recent data in adults point the same way. SUMMARY: This review describes the recent clinical results of cord blood transplantation and discusses developing research strategies aimed at optimizing this kind of transplantation.
Authors: Mary Eapen; John P Klein; Guillermo F Sanz; Stephen Spellman; Annalisa Ruggeri; Claudio Anasetti; Maria Brown; Richard E Champlin; Joan Garcia-Lopez; Gareth Hattersely; Gesine Koegler; Mary J Laughlin; Gerard Michel; Samir K Nabhan; Franklin O Smith; Mary M Horowitz; Eliane Gluckman; Vanderson Rocha Journal: Lancet Oncol Date: 2011-10-06 Impact factor: 41.316
Authors: Rowayda Peters; Monika J Wolf; Maries van den Broek; Mario Nuvolone; Stefanie Dannenmann; Bruno Stieger; Reto Rapold; Daniel Konrad; Arnold Rubin; Joseph R Bertino; Adriano Aguzzi; Mathias Heikenwalder; Alexander K Knuth Journal: PLoS One Date: 2010-12-30 Impact factor: 3.240