BACKGROUND: It is unclear whether there are early clinical features that can distinguish between patients with familial and non-familial frontotemporal dementia (FTD). OBJECTIVE: To compare the clinical features of FTD cases who have tau gene mutations with those of cases with a family history of FTD but no tau gene mutation, and with sporadic cases with neither feature. METHODS AND RESULTS: Comparisons of the behavioural, cognitive, and motor features in 32 FTD patients (five positive for tau gene mutations, nine familial but tau negative, and 18 tau negative sporadic) showed that age of onset and duration to diagnosis did not differ between the groups. Apathy was not observed in tau mutation positive cases, and dysexecutive signs were more frequent in familial tau mutation negative cases. Memory deficits and behavioural changes were common in all groups. CONCLUSIONS: In comparison with other neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, neither tau gene mutations nor strong familial associations confer earlier disease susceptibility.
BACKGROUND: It is unclear whether there are early clinical features that can distinguish between patients with familial and non-familial frontotemporal dementia (FTD). OBJECTIVE: To compare the clinical features of FTD cases who have tau gene mutations with those of cases with a family history of FTD but no tau gene mutation, and with sporadic cases with neither feature. METHODS AND RESULTS: Comparisons of the behavioural, cognitive, and motor features in 32 FTD patients (five positive for tau gene mutations, nine familial but tau negative, and 18 tau negative sporadic) showed that age of onset and duration to diagnosis did not differ between the groups. Apathy was not observed in tau mutation positive cases, and dysexecutive signs were more frequent in familial tau mutation negative cases. Memory deficits and behavioural changes were common in all groups. CONCLUSIONS: In comparison with other neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, neither tau gene mutations nor strong familial associations confer earlier disease susceptibility.
Authors: Andrea Slachevsky; Carlos Muñoz-Neira; Javier Nuñez-Huasaf; Theodore A Stern; Carl R Blesius; Alireza Atri Journal: Prim Care Companion CNS Disord Date: 2011
Authors: Rosa Capozzo; Celeste Sassi; Monia B Hammer; Simona Arcuti; Chiara Zecca; Maria R Barulli; Rosanna Tortelli; J Raphael Gibbs; Cynthia Crews; Davide Seripa; Francesco Carnicella; Claudia Dell'Aquila; Marco Rossi; Filippo Tamma; Francesco Valluzzi; Bruno Brancasi; Francesco Panza; Andrew B Singleton; Giancarlo Logroscino Journal: Alzheimers Dement Date: 2017-03-03 Impact factor: 21.566
Authors: S Davion; N Johnson; S Weintraub; M-M Mesulam; A Engberg; M Mishra; M Baker; J Adamson; M Hutton; R Rademakers; E H Bigio Journal: Neurology Date: 2007-05-23 Impact factor: 9.910
Authors: Maura Malpetti; P Simon Jones; Kamen A Tsvetanov; Timothy Rittman; John C van Swieten; Barbara Borroni; Raquel Sanchez-Valle; Fermin Moreno; Robert Laforce; Caroline Graff; Matthis Synofzik; Daniela Galimberti; Mario Masellis; Maria Carmela Tartaglia; Elizabeth Finger; Rik Vandenberghe; Alexandre de Mendonça; Fabrizio Tagliavini; Isabel Santana; Simon Ducharme; Chris R Butler; Alexander Gerhard; Johannes Levin; Adrian Danek; Markus Otto; Giovanni B Frisoni; Roberta Ghidoni; Sandro Sorbi; Carolin Heller; Emily G Todd; Martina Bocchetta; David M Cash; Rhian S Convery; Georgia Peakman; Katrina M Moore; Jonathan D Rohrer; Rogier A Kievit; James B Rowe Journal: Alzheimers Dement Date: 2020-12-14 Impact factor: 16.655