Literature DB >> 15548264

Immunoregulatory cytokine polymorphisms in Italian patients affected by paroxysmal nocturnal haemoglobinuria and aplastic anaemia.

E Fermo1, P Bianchi, W Barcellini, P Pedotti, C Boschetti, F Alfinito, A Cortelezzi, A Zanella.   

Abstract

We investigated regulatory variants of five cytokine genes [tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, interleukin (IL)-6 and IL-10] in 40 Italian patients affected by paroxysmal nocturnal haemoglobinuria (PNH) and aplastic anaemia (AA). Genotypes associated with high production of TGF-beta and IFN-gamma were more frequent in patients than in controls. Genetic regulation of the immunological pathways involved in the pathogenesis of bone marrow failure is suggested.

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Year:  2004        PMID： 15548264     DOI： 10.1111/j.1365-2370.2004.00480.x

Source DB:  PubMed          Journal:  Eur J Immunogenet        ISSN： 0960-7420


  6 in total

1.  Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia.

Authors:  Manuel G Afable; Mohammed Shaik; Yuka Sugimoto; Paul Elson; Michael Clemente; Hideki Makishima; Mikkael A Sekeres; Alan Lichtin; Anjali Advani; Matt Kalaycio; Ramon V Tiu; Christine L O'Keefe; Jaroslaw P Maciejewski
Journal:  Haematologica       Date:  2011-05-23       Impact factor: 9.941

2.  IFN-γ causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation.

Authors:  Fan-ching Lin; Megan Karwan; Bahara Saleh; Deborah L Hodge; Tim Chan; Kimberly C Boelte; Jonathan R Keller; Howard A Young
Journal:  Blood       Date:  2014-10-23       Impact factor: 22.113

Review 3.  Inflammatory signals regulate hematopoietic stem cells.

Authors:  Megan T Baldridge; Katherine Y King; Margaret A Goodell
Journal:  Trends Immunol       Date:  2011-01-11       Impact factor: 16.687

4.  Interferon-gamma-induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles.

Authors:  Weihua Zeng; Akira Miyazato; Guibin Chen; Sachiko Kajigaya; Neal S Young; Jaroslaw P Maciejewski
Journal:  Blood       Date:  2005-08-30       Impact factor: 22.113

Review 5.  Immune pathogenesis of paroxysmal nocturnal hemoglobinuria.

Authors:  Ramon Tiu; Jaroslaw Maciejewski
Journal:  Int J Hematol       Date:  2006-08       Impact factor: 2.490

Review 6.  Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia.

Authors:  Irene Mavroudi; Helen A Papadaki
Journal:  Clin Dev Immunol       Date:  2012-08-26
  6 in total

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