| Literature DB >> 15546720 |
Elfatih Elzein1, Prabha Ibrahim, Dmitry O Koltun, Ken Rehder, Kevin D Shenk, Timothy A Marquart, Bob Jiang, Xiaofen Li, Reina Natero, Yuan Li, Marie Nguyen, Suresh Kerwar, Nancy Chu, Daniel Soohoo, Jia Hao, Victoria Y Maydanik, David A Lustig, Dewan Zeng, Kwan Leung, Jeff A Zablocki.
Abstract
New inhibitors of palmitoyl-CoA oxidation are based on the introduction of nitrogen heterocycles in the 'Western Portion' of the molecule. SAR studies led to the discovery of CVT-4325 (shown), a potent FOXi (IC50=380 nM rat mitochondria) with favorable PK properties (F=93%, t(1/2)=13.6h, dog).Entities:
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Year: 2004 PMID： 15546720 DOI： 10.1016/j.bmcl.2004.09.077
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823