BACKGROUND: The aim of this study was to determine the surgical risks and long-term survival in alcoholic patients undergoing resection for non-small-cell lung cancer. METHODS: Nineteen resected patients comprising the alcoholic group were identified by either a Diagnostic and Statistical Manual of Mental Disorders-IV diagnosis of alcohol dependence/abuse, or an alcohol consumption of 60 oz/d or more. Alcoholic patients were compared with 37 nonalcoholic patients undergoing resection. RESULTS: Alcoholic patients had an increase in major infectious complications (37% [7 of 19] versus 5% [2 of 37], P = 0.005), respiratory failure (42% [8 of 19] versus 5% [2 of 37], P </=0.001), and costs ($49,526 +/- $17,525 versus $18,385 +/- $3,260, P = 0.01). Alcohol abuse was the best predictor of perioperative respiratory and infectious complications (P = 0.002, B = 2.86, odds ratio = 17.5). Stage of disease (P = 0.03, B = 1.19, hazard ratio = 3.29) was a better predictor of long-term survival. CONCLUSIONS: Alcohol abuse significantly increases the risk and cost of lung cancer resection. For alcoholic patients surviving the perioperative period, long-term survival appears similar to non-alcohol-abusing patients.
BACKGROUND: The aim of this study was to determine the surgical risks and long-term survival in alcoholicpatients undergoing resection for non-small-cell lung cancer. METHODS: Nineteen resected patients comprising the alcoholic group were identified by either a Diagnostic and Statistical Manual of Mental Disorders-IV diagnosis of alcohol dependence/abuse, or an alcohol consumption of 60 oz/d or more. Alcoholicpatients were compared with 37 nonalcoholic patients undergoing resection. RESULTS:Alcoholicpatients had an increase in major infectious complications (37% [7 of 19] versus 5% [2 of 37], P = 0.005), respiratory failure (42% [8 of 19] versus 5% [2 of 37], P </=0.001), and costs ($49,526 +/- $17,525 versus $18,385 +/- $3,260, P = 0.01). Alcohol abuse was the best predictor of perioperative respiratory and infectious complications (P = 0.002, B = 2.86, odds ratio = 17.5). Stage of disease (P = 0.03, B = 1.19, hazard ratio = 3.29) was a better predictor of long-term survival. CONCLUSIONS:Alcohol abuse significantly increases the risk and cost of lung cancer resection. For alcoholicpatients surviving the perioperative period, long-term survival appears similar to non-alcohol-abusing patients.
Authors: Bharath Nath; YouFu Li; James E Carroll; Gyongyi Szabo; Jennifer F Tseng; Shimul A Shah Journal: J Gastrointest Surg Date: 2010-09-14 Impact factor: 3.452
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Authors: Marc Licker; Alexandre Schweizer; Christoph Ellenberger; Jean-Marie Tschopp; John Diaper; François Clergue Journal: Int J Chron Obstruct Pulmon Dis Date: 2007