OBJECTIVE: Our purpose was to analyze the predictive factors of severe upper gastrointestinal injury by caustic substances in adult patients. PATIENTS AND METHOD: Retrospective study between February 1995 and February 2001 of adult patients who underwent an urgent upper endoscopy due to caustic ingestion. Endoscopic caustic ingestion criteria by Zargar et al were used to determine the degree of injury. We performed a univariate study of factors associated with sever digestive injury and, lately, a logistic regression analysis of predictive factors. Sensitivity, specificity, positive and negative predictive values of these factors were calculated. RESULTS: One hundred and fifty nine patients were included in the study, whose mean age was 48.9 (20.1) years and 49.7% were men. The more frequent caustic ingested was lye (47.8%). A severe caustic injury was found in urgent upper endoscopy in 18.4% of patients, which was located in esophagus in 14.6%, stomach in 8.2% and duodenum in 0.6% of cases. Male sex, voluntary ingestion, oropharingeal lesions, significant clinical symptoms and dishwasher and detergents ingestion were associated with severe upper gastrointestinal tract (GIT) injury. Voluntary ingestion, oropharingeal lesions and significant clinical symptoms at admission were independent predictive factors of severe GIT injury. The existence of one of these factors had an 89.7% of sensitivity while two or more displayed a specificity of 91%. CONCLUSIONS: Clinical and exploratory data may determine, before upper endoscopic procedure, the probability of severe GIT injury by caustic ingestion. Therefore, these data could play a significant role in the diagnostic, prognostic and therapeutic management of caustic ingestion.
OBJECTIVE: Our purpose was to analyze the predictive factors of severe upper gastrointestinal injury by caustic substances in adult patients. PATIENTS AND METHOD: Retrospective study between February 1995 and February 2001 of adult patients who underwent an urgent upper endoscopy due to caustic ingestion. Endoscopic caustic ingestion criteria by Zargar et al were used to determine the degree of injury. We performed a univariate study of factors associated with sever digestive injury and, lately, a logistic regression analysis of predictive factors. Sensitivity, specificity, positive and negative predictive values of these factors were calculated. RESULTS: One hundred and fifty nine patients were included in the study, whose mean age was 48.9 (20.1) years and 49.7% were men. The more frequent caustic ingested was lye (47.8%). A severe caustic injury was found in urgent upper endoscopy in 18.4% of patients, which was located in esophagus in 14.6%, stomach in 8.2% and duodenum in 0.6% of cases. Male sex, voluntary ingestion, oropharingeal lesions, significant clinical symptoms and dishwasher and detergents ingestion were associated with severe upper gastrointestinal tract (GIT) injury. Voluntary ingestion, oropharingeal lesions and significant clinical symptoms at admission were independent predictive factors of severe GIT injury. The existence of one of these factors had an 89.7% of sensitivity while two or more displayed a specificity of 91%. CONCLUSIONS: Clinical and exploratory data may determine, before upper endoscopic procedure, the probability of severe GIT injury by caustic ingestion. Therefore, these data could play a significant role in the diagnostic, prognostic and therapeutic management of caustic ingestion.
Authors: Mircea Chirica; Matthieu Resche-Rigon; Benjamin Pariente; Fabienne Fieux; François Sabatier; Franck Loiseaux; Nicolas Munoz-Bongrand; Jean Marc Gornet; Marie-Dominique Brette; Emile Sarfati; Elie Azoulay; Anne Marie Zagdanski; Pierre Cattan Journal: Surg Endosc Date: 2014-08-27 Impact factor: 4.584
Authors: Yoram Kluger; Ofir Ben Ishay; Massimo Sartelli; Amit Katz; Luca Ansaloni; Carlos Augusto Gomez; Walter Biffl; Fausto Catena; Gustavo P Fraga; Salomone Di Saverio; Augustin Goran; Wagih Ghnnam; Jeffry Kashuk; Ari Leppäniemi; Sanjay Marwah; Ernest E Moore; Miklosh Bala; Damien Massalou; Chirica Mircea; Luigi Bonavina Journal: World J Emerg Surg Date: 2015-10-16 Impact factor: 5.469
Authors: Marcus Hollenbach; Jan Tünnemann; Manuel Florian Struck; Jürgen Feisthammel; Tobias Schlosser; Tiffany Schaumburg; Joachim Mössner; Albrecht Hoffmeister Journal: Medicine (Baltimore) Date: 2019-08 Impact factor: 1.817