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Literature DB >> 15546395

Signaling pathways in Th2 development.

Abstract

In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.

Entities: Gene

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Year: 2004 PMID： 15546395 DOI： 10.1111/j.0105-2896.2004.00209.x

Source DB: PubMed Journal: Immunol Rev ISSN： 0105-2896 Impact factor: 12.988

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Cited

79 in total

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Journal: Immunology Date: 2011-11 Impact factor: 7.397

Review 2. Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression.

Authors: Kartika Padhan; Rajat Varma
Journal: Immunology Date: 2010-03 Impact factor: 7.397

3. Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.

Authors: Deborah W Hendricks; Pamela J Fink
Journal: Blood Date: 2010-11-03 Impact factor: 22.113

Review 4. Immunogenomics and systems biology of vaccines.

Authors: Luigi Buonaguro; Bali Pulendran
Journal: Immunol Rev Date: 2011-01 Impact factor: 12.988

5. Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion.

Authors: Jinfang Zhu; Dragana Jankovic; Alex Grinberg; Liying Guo; William E Paul
Journal: Proc Natl Acad Sci U S A Date: 2006-11-20 Impact factor: 11.205

6. The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.

Authors: David J Rawlings
Journal: EMBO Rep Date: 2006-01 Impact factor: 8.807

Signaling pathways in Th2 development.

Review 1. Helper T-cell differentiation and plasticity: insights from epigenetics.

Review 2. Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression.

3. Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.

Review 4. Immunogenomics and systems biology of vaccines.

5. Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion.

6. The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.

7. Demethylation of a specific hypersensitive site in the Th2 locus control region.

Review 8. A tale of two cytokines: IL-17 and IL-22 in asthma and infection.

Review 9. SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels.

Review 10. Dendritic cell modulation as a new interventional approach for the treatment of asthma.