Literature DB >> 15545003

Immediate early gene expression in rat basal ganglia after destruction of the dopaminergic system.

V Pedersen1, W J Schmidt.   

Abstract

In the present study, we performed immunocytochemical mapping of cFos and c-Jun as markers for changes in neural activity in the brains of dopamine denervated rats. We observed a prolonged c-Fos and c-Jun expression in basal ganglia motor and limbic circuits over 96 h. This might be due to alterations in transmitter balances. We conclude, that changes in neural activities are involved in the development of 'extranigral' pathology of Parkinson's disease.

Entities:  

Year:  2000        PMID： 15545003     DOI： 10.1007/bf03033324

Source DB:  PubMed          Journal:  Neurotox Res        ISSN： 1029-8428            Impact factor:   3.911


  9 in total

Review 1.  Pattern of brain destruction in Parkinson's and Alzheimer's diseases.

Authors:  H Braak; E Braak; D Yilmazer; R A de Vos; E N Jansen; J Bohl
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

Review 2.  Behavioural pharmacology of glutamate receptors in the basal ganglia.

Authors:  W J Schmidt; B D Kretschmer
Journal:  Neurosci Biobehav Rev       Date:  1997-07       Impact factor: 8.989

3.  Prolonged expression of Fos-related antigens, Jun B and TrkB in dopamine-denervated striatal neurons.

Authors:  M Dragunow; N Butterworth; H Waldvogel; R L Faull; L F Nicholson
Journal:  Brain Res Mol Brain Res       Date:  1995-06

4.  c-jun expression in substantia nigra neurons following striatal 6-hydroxydopamine lesions in the rat.

Authors:  R Jenkins; R O'Shea; K L Thomas; S P Hunt
Journal:  Neuroscience       Date:  1993-03       Impact factor: 3.590

Review 5.  The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments.

Authors:  R K Schwarting; J P Huston
Journal:  Prog Neurobiol       Date:  1996-10       Impact factor: 11.685

6.  Elevated striatal Fos immunoreactivity following 6-hydroxydopamine lesioning of the rat is mediated by excitatory amino acid transmission.

Authors:  A J Cooper; S Wooller; I J Mitchell
Journal:  Neurosci Lett       Date:  1995-07-14       Impact factor: 3.046

Review 7.  Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.

Authors:  T Herdegen; J D Leah
Journal:  Brain Res Brain Res Rev       Date:  1998-12

8.  Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine.

Authors:  G R Breese; T D Traylor
Journal:  Br J Pharmacol       Date:  1971-05       Impact factor: 8.739

9.  Reserpine increases Fos activity in the rat basal ganglia via a quinpirole-sensitive mechanism.

Authors:  D G Cole; M Di Figlia
Journal:  Neuroscience       Date:  1994-05       Impact factor: 3.590
  9 in total

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