| Literature DB >> 15544568 |
Todd A Swanson1, Sandra I Kim, Michael Myers, Amanda Pabon, Keith D Philibert, Mina Wang, Marc J Glucksman.
Abstract
The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The "neural" prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs.Entities:
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Year: 2004 PMID： 15544568 DOI： 10.2174/0929866043406607
Source DB: PubMed Journal: Protein Pept Lett ISSN： 0929-8665 Impact factor: 1.890