Literature DB >> 15544563

Secretase-mediated cell surface shedding of the angiotensin-converting enzyme.

Edward T Parkin1, Anthony J Turner, Nigel M Hooper.   

Abstract

Angiotensin-converting enzyme (ACE) is an example of a membrane-bound protein, which is shed from the cell surface in a soluble form by a post-translational proteolytic cleavage event involving a secretase. The secretase cleavage site in somatic ACE has been mapped to Arg-1203/Ser-1204, 24 residues proximal to the membrane-anchoring domain and the ADAM ('a disintegrin and metalloprotease') family of proteins may be involved in ACE shedding.

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Year:  2004        PMID： 15544563     DOI： 10.2174/0929866043406544

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  19 in total

1.  ACE phenotyping in Gaucher disease.

Authors:  Sergei M Danilov; Victoria E Tikhomirova; Roman Metzger; Irina A Naperova; Tatiana M Bukina; Ozlem Goker-Alpan; Nahid Tayebi; Nurshat M Gayfullin; David E Schwartz; Larisa M Samokhodskaya; Olga A Kost; Ellen Sidransky
Journal:  Mol Genet Metab       Date:  2018-02-17       Impact factor: 4.797

Review 2.  Angiotensin-converting enzyme in innate and adaptive immunity.

Authors:  Kenneth E Bernstein; Zakir Khan; Jorge F Giani; Duo-Yao Cao; Ellen A Bernstein; Xiao Z Shen
Journal:  Nat Rev Nephrol       Date:  2018-03-26       Impact factor: 28.314

3.  Surfactant protein A (SP-A) and angiotensin converting enzyme (ACE) as early biomarkers for pulmonary edema formation in ventilated human lung lobes.

Authors:  Mirjam Gnadt; Boris Kardziev; Michael Schmidt; Petra Högger
Journal:  Lung       Date:  2012-04-01       Impact factor: 2.584

Review 4.  A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme.

Authors:  Kenneth E Bernstein; Frank S Ong; Wendell-Lamar B Blackwell; Kandarp H Shah; Jorge F Giani; Romer A Gonzalez-Villalobos; Xiao Z Shen; Sebastien Fuchs; Rhian M Touyz
Journal:  Pharmacol Rev       Date:  2012-12-20       Impact factor: 25.468

5.  Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes.

Authors:  Scott Miners; Emma Ashby; Shabnam Baig; Rachel Harrison; Hannah Tayler; Elizabeth Speedy; Jonathan A Prince; Seth Love; Patrick G Kehoe
Journal:  Am J Transl Res       Date:  2009-01-18       Impact factor: 4.060

6.  A small region in the angiotensin-converting enzyme distal ectodomain is required for cleavage-secretion of the protein at the plasma membrane.

Authors:  Saurabh Chattopadhyay; Goutam Karan; Indira Sen; Ganes C Sen
Journal:  Biochemistry       Date:  2008-07-18       Impact factor: 3.162

7.  Conformational changes of blood ACE in chronic uremia.

Authors:  Maxim N Petrov; Valery Y Shilo; Alexandr V Tarasov; David E Schwartz; Joe G N Garcia; Olga A Kost; Sergei M Danilov
Journal:  PLoS One       Date:  2012-11-16       Impact factor: 3.240

8.  A novel splice-site mutation in angiotensin I-converting enzyme (ACE) gene, c.3691+1G>A (IVS25+1G>A), causes a dramatic increase in circulating ACE through deletion of the transmembrane anchor.

Authors:  Alexandre Persu; Michel Lambert; Jaap Deinum; Marta Cossu; Nathalie de Visscher; Leonid Irenge; Jerôme Ambroise; Jean-Marc Minon; Andrew B Nesterovitch; Alexander Churbanov; Isolda A Popova; Sergei M Danilov; A H Jan Danser; Jean-Luc Gala
Journal:  PLoS One       Date:  2013-04-01       Impact factor: 3.240

9.  Angiotensin I-converting enzyme mutation (Trp1197Stop) causes a dramatic increase in blood ACE.

Authors:  Andrew B Nesterovitch; Kyle D Hogarth; Vyacheslav A Adarichev; Elena I Vinokour; David E Schwartz; Julian Solway; Sergei M Danilov
Journal:  PLoS One       Date:  2009-12-14       Impact factor: 3.240

10.  The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi.

Authors:  Julio Scharfstein; Daniele Andrade; Erik Svensjö; Ana Carolina Oliveira; Clarissa R Nascimento
Journal:  Front Immunol       Date:  2013-01-25       Impact factor: 7.561
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