Literature DB >> 15544558

Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists.

Marlon Cowart1, Robert Altenbach, Lawrence Black, Ramin Faghih, Chen Zhao, Arthur A Hancock.   

Abstract

The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.

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Year:  2004        PMID： 15544558     DOI： 10.2174/1389557043403215

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  11 in total

1.  Search for novel, high affinity histamine H3 receptor ligands with fluorescent properties.

Authors:  K J Kuder; T Kottke; H Stark; X Ligneau; J-C Camelin; R Seifert; K Kieć-Kononowicz
Journal:  Inflamm Res       Date:  2010-03       Impact factor: 4.575

Review 2.  The histamine H3 receptor: an attractive target for the treatment of cognitive disorders.

Authors:  T A Esbenshade; K E Browman; R S Bitner; M Strakhova; M D Cowart; J D Brioni
Journal:  Br J Pharmacol       Date:  2008-05-12       Impact factor: 8.739

3.  Processing of NMR and MS metabolomics data using chemometrics methods: a global tool for fungi biotransformation reactions monitoring.

Authors:  Cécile Palaric; Serge Pilard; Jean-Xavier Fontaine; Julien Boccard; David Mathiron; Sébastien Rigaud; Dominique Cailleu; François Mesnard; Yoann Gut; Tristan Renaud; Alain Petit; Jean-Yves Beaumal; Roland Molinié
Journal:  Metabolomics       Date:  2019-07-25       Impact factor: 4.290

Review 4.  Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.

Authors:  Mohammad A Khanfar; Anna Affini; Kiril Lutsenko; Katarina Nikolic; Stefania Butini; Holger Stark
Journal:  Front Neurosci       Date:  2016-05-30       Impact factor: 4.677

5.  Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes.

Authors:  Ashwin U Rao; Ning Shao; Robert G Aslanian; Tin-Yau Chan; Sylvia J Degrado; Li Wang; Brian McKittrick; Mary Senior; Robert E West; Shirley M Williams; Ren-Long Wu; Joyce Hwa; Bhuneshwari Patel; Shuqin Zheng; Christopher Sondey; Anandan Palani
Journal:  ACS Med Chem Lett       Date:  2011-11-21       Impact factor: 4.345

6.  Histamine and its receptors.

Authors:  Mike E Parsons; C Robin Ganellin
Journal:  Br J Pharmacol       Date:  2006-01       Impact factor: 8.739

7.  In vitro and in vivo pharmacological analysis of imidazole-free histamine H3 receptor antagonists: promising results for a brain-penetrating H3 blocker with weak anticholinesterase activity.

Authors:  Simona Bertoni; Vigilio Ballabeni; Lisa Flammini; Francesca Saccani; Giuseppe Domenichini; Giovanni Morini; Mara Comini; Mirko Rivara; Elisabetta Barocelli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-05-22       Impact factor: 3.000

8.  Generation of a homology model of the human histamine H(3) receptor for ligand docking and pharmacophore-based screening.

Authors:  Birgit Schlegel; Christian Laggner; Rene Meier; Thierry Langer; David Schnell; Roland Seifert; Holger Stark; Hans-Dieter Höltje; Wolfgang Sippl
Journal:  J Comput Aided Mol Des       Date:  2007-08-01       Impact factor: 3.686

9.  Single dose of H3 receptor antagonist--ciproxifan--abolishes negative effects of chronic stress on cognitive processes in rats.

Authors:  Emil Trofimiuk; Jan J Braszko
Journal:  Psychopharmacology (Berl)       Date:  2013-08-24       Impact factor: 4.530

10.  Design, synthesis, and in vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H3 receptor antagonists.

Authors:  Marek Staszewski; Anna Stasiak; Tadeusz Karcz; Daniel McNaught Flores; Wiesława Agnieszka Fogel; Katarzyna Kieć-Kononowicz; Rob Leurs; Krzysztof Walczyński
Journal:  Medchemcomm       Date:  2019-01-11       Impact factor: 3.597
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