Literature DB >> 1554407

Formation of stable p53 homotetramers and multiples of tetramers.

J E Stenger1, G A Mayr, K Mann, P Tegtmeyer.   

Abstract

We have used gradient gel electrophoresis and chemical cross-linking to analyze the quaternary structure of purified, wild-type, murine p53. Under nondenaturing conditions, p53 electrophoreses as tetramers and multiples of tetramers. Under denaturing conditions, fully cross-linked p53 also behaves as tetrameric structures. We confirmed the composition of the tetramers by partially cross-linking p53 and dissociating tetramers into monomers, dimers, and trimers.

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Year:  1992        PMID： 1554407     DOI： 10.1002/mc.2940050204

Source DB:  PubMed          Journal:  Mol Carcinog        ISSN： 0899-1987            Impact factor:   4.784


  38 in total

1.  Role of tumor suppressor p53 domains in selective binding to supercoiled DNA.

Authors:  Marie Brázdová; Jan Palecek; Dmitry I Cherny; Sabina Billová; Miroslav Fojta; Petr Pecinka; Borivoj Vojtesek; Thomas M Jovin; Emil Palecek
Journal:  Nucleic Acids Res       Date:  2002-11-15       Impact factor: 16.971

2.  A transcriptionally active DNA-binding site for human p53 protein complexes.

Authors:  W D Funk; D T Pak; R H Karas; W E Wright; J W Shay
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

3.  The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis.

Authors:  Siddharth Singh; Manoj Kumar; Sanjeev Kumar; Shrinka Sen; Pawan Upadhyay; Sayan Bhattacharjee; Naveen M; Vivek Singh Tomar; Siddhartha Roy; Amit Dutt; Tapas K Kundu
Journal:  J Biol Chem       Date:  2019-07-31       Impact factor: 5.157

4.  Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination.

Authors:  C Dudenhöffer; G Rohaly; K Will; W Deppert; L Wiesmüller
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

5.  Differential interaction of temperature-sensitive simian virus 40 T antigens with tumor suppressors pRb and p53.

Authors:  S Ray; M E Anderson; P Tegtmeyer
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

6.  Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation.

Authors:  M E Anderson; B Woelker; M Reed; P Wang; P Tegtmeyer
Journal:  Mol Cell Biol       Date:  1997-11       Impact factor: 4.272

7.  Oligomerization of the transcription termination factor TTF-I: implications for the structural organization of ribosomal transcription units.

Authors:  E E Sander; I Grummt
Journal:  Nucleic Acids Res       Date:  1997-03-15       Impact factor: 16.971

8.  Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA.

Authors:  D Parks; R Bolinger; K Mann
Journal:  Nucleic Acids Res       Date:  1997-03-15       Impact factor: 16.971

9.  Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells.

Authors:  M Bai; B Harfe; P Freimuth
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

10.  Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.

Authors:  T Unger; J A Mietz; M Scheffner; C L Yee; P M Howley
Journal:  Mol Cell Biol       Date:  1993-09       Impact factor: 4.272
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