Literature DB >> 15544052

Synthesis and pharmacological investigation of some novel 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones as histamine H1-receptor blockers.

V Alagarsamy1.   

Abstract

A series of 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones were synthesized from 3-amino-2-methyl-(3H)-quinazolin-4-one. Their structures were confirmed by spectral data (IR, NMR and MS) and the purity was ascertained by microanalysis. When tested for H1-receptor blocking activity on isolated guinea pig ileum all the test compounds inhibited histamine induced contraction whereas compound 5 (IC50 0.22 x 10(3) ng/ml) was found to be four times more potent than chlorpheniramine maleate (IC50 1 x 10(3) ng/ml) and it showed lesser sedation (8%) than the standard (32%).

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15544052

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  6 in total

1.  A three component one-pot procedure for the synthesis of [1,2,4]triazolo/benzimidazolo-quinazolinone derivatives in the presence of H6P2W18O(62).18H2O as a green and reusable catalyst.

Authors:  Majid M Heravi; Leila Ranjbar; Fatemeh Derikvand; Behnoush Alimadadi; Hossien A Oskooie; Fatemeh F Bamoharram
Journal:  Mol Divers       Date:  2008-09-09       Impact factor: 2.943

2.  Nano-[Fe3O4@SiO2/N-propyl-1-(thiophen-2-yl)ethanimine][ZnCl2] as a nano magnetite Schiff base complex and heterogeneous catalyst for the synthesis of pyrimido[4,5-b]quinolones.

Authors:  Soheila Esmaili; Ahmad Reza Moosavi-Zare; Ardeshir Khazaei
Journal:  RSC Adv       Date:  2022-02-14       Impact factor: 3.361

3.  Preparation, characterization, and use of novel Cu@Fe3O4 MNPs in the synthesis of tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H)-ones and 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions.

Authors:  Lilin Jiang; Zumrat Druzhinin
Journal:  RSC Adv       Date:  2019-05-14       Impact factor: 4.036

4.  One-pot synthesis of 2-substituted 4H-3,1-benzoxazin-4-one derivatives under mild conditions using iminium cation from cyanuric chloride/dimethylformamide as a cyclizing agent.

Authors:  Mehdi Shariat; Mohd Wahid Samsudin; Zuriati Zakaria
Journal:  Chem Cent J       Date:  2013-03-27       Impact factor: 4.215

5.  Biological effects of a new set 1,2,4-triazolo[1,5-a]quinazolines on heart rate and blood pressure.

Authors:  Rashad Al-Salahi; Kamal-Eldin El-Tahir; Ibrahim Alswaidan; Nabih Lolak; Mohammed Hamidaddin; Mohamed Marzouk
Journal:  Chem Cent J       Date:  2014-01-15       Impact factor: 4.215

6.  Synthesis and antihypertensive screening of new derivatives of quinazolines linked with isoxazole.

Authors:  Mujeeb Ur Rahman; Ankita Rathore; Anees A Siddiqui; Gazala Parveen; M Shahar Yar
Journal:  Biomed Res Int       Date:  2014-06-12       Impact factor: 3.411
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.