Literature DB >> 1554364

Evidence for two cDNA clones encoding human GM2-activator protein.

S Nagarajan1, H C Chen, S C Li, Y T Li, J M Lockyer.   

Abstract

Two cDNAs encoding GM2 activator, pGM2A (648 bp) and GAP (1093 bp), were isolated from human placenta lambda gt11 libraries. The DNA sequence of pGM2A from 1 to 302 was almost identical with GAP, but diverged from 303-648. PCR was used to demonstrate the presence of both species of GM2 activator in placental RNA. Both cDNAs hybridized to mRNAs of approximately 2.3 kb and to identical single bands on genomic Southern blots.

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Year:  1992        PMID： 1554364      PMCID： PMC1130859          DOI： 10.1042/bj2820807

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  42 in total

1.  Purification and fractionation of poly(A)+ RNA.

Authors:  A Jacobson
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

2.  Saposin A: second cerebrosidase activator protein.

Authors:  S Morimoto; B M Martin; Y Yamamoto; K A Kretz; J S O'Brien; Y Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

3.  Characterization of an activating factor required for hydrolysis of Gm2 ganglioside catalyzed by hexosaminidase A.

Authors:  P Hechtman
Journal:  Can J Biochem       Date:  1977-04

4.  Activator protein required for the enzymatic hydrolysis of cerebroside sulfate. Deficiency in urine of patients affected with cerebroside sulfatase activator deficiency and identity with activators for the enzymatic hydrolysis of GM1 ganglioside and globotriaosylceramide.

Authors:  S C Li; H Kihara; S Serizawa; Y T Li; A L Fluharty; J S Mayes; L J Shapiro
Journal:  J Biol Chem       Date:  1985-02-10       Impact factor: 5.157

5.  Purification and properties of a heat-stable glucocerebrosidase activating factor from control and Gaucher spleen.

Authors:  S P Peters; P Coyle; C J Coffee; R H Glew
Journal:  J Biol Chem       Date:  1977-01-25       Impact factor: 5.157

6.  Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus.

Authors:  J S O'Brien; K A Kretz; N Dewji; D A Wenger; F Esch; A L Fluharty
Journal:  Science       Date:  1988-08-26       Impact factor: 47.728

7.  The protein activator specific for the enzymic hydrolysis of GM2 ganglioside in normal human brain and brains of three types of GM2 gangliosidosis.

Authors:  Y Hirabayashi; Y T Li; S C Li
Journal:  J Neurochem       Date:  1983-01       Impact factor: 5.372

8.  Purification and characterization of an activator protein for the degradation of glycolipids GM2 and GA2 by hexosaminidase A.

Authors:  E Conzelmann; K Sandhoff
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1979-12

9.  Structure of full-length cDNA coding for sulfatide activator, a Co-beta-glucosidase and two other homologous proteins: two alternate forms of the sulfatide activator.

Authors:  T Nakano; K Sandhoff; J Stümper; H Christomanou; K Suzuki
Journal:  J Biochem       Date:  1989-02       Impact factor: 3.387

10.  A protein activator of galactosylceramide beta-galactosidase.

Authors:  D A Wenger; M Sattler; S Roth
Journal:  Biochim Biophys Acta       Date:  1982-09-14
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  7 in total

1.  Cloning and sequence analysis of a cDNA clone coding for the mouse GM2 activator protein.

Authors:  G Bellachioma; J L Stirling; A Orlacchio; T Beccari
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

2.  Complete localization of disulfide bonds in GM2 activator protein.

Authors:  C G Schütte; T Lemm; G J Glombitza; K Sandhoff
Journal:  Protein Sci       Date:  1998-04       Impact factor: 6.725

3.  Structure of the GM2A gene: identification of an exon 2 nonsense mutation and a naturally occurring transcript with an in-frame deletion of exon 2.

Authors:  B Chen; B Rigat; C Curry; D J Mahuran
Journal:  Am J Hum Genet       Date:  1999-07       Impact factor: 11.025

4.  Study of interaction of GM2 activator protein with GM2 using circular dichroism and fluorescence spectroscopy.

Authors:  Daniela Ravasi; Massimo Masserini; Giuseppe Vecchio; Yu-Teh Li; Su-Chen Li
Journal:  Neurochem Res       Date:  2002-08       Impact factor: 3.996

5.  Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility.

Authors:  Yu-Teh Li; Su-Chen Li; Makoto Kiso; Hideharu Ishida; Laura Mauri; Laura Raimondi; Anna Bernardi; Sandro Sonnino
Journal:  Biochim Biophys Acta       Date:  2007-10-05

6.  Structural organization and expression of the gene for the mouse GM2 activator protein.

Authors:  C Bertoni; M G Appolloni; J L Stirling; S C Li; Y T Li; A Orlacchio; T Beccari
Journal:  Mamm Genome       Date:  1997-02       Impact factor: 2.957

7.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1992-06-25       Impact factor: 16.971
  7 in total

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