Literature DB >> 15543155

Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin.

Kara S Giddings1, Ji Zhao, Peter J Sims, Rodney K Tweten.   

Abstract

Cholesterol is believed to serve as the common receptor for the cholesterol-dependent cytolysins (CDCs). One member of this toxin family, Streptococcus intermedius intermedilysin (ILY), exhibits a narrow spectrum of cellular specificity that is seemingly inconsistent with this premise. We show here that ILY, via its domain 4 structure, binds to the glycosyl-phosphatidylinositol-linked membrane protein human CD59 (huCD59). CD59 is an inhibitor of the membrane attack complex of human complement. ILY specifically binds to huCD59 via residues that are the binding site for the C8alpha and C9 complement proteins. These studies provide a new model for the mechanism of cellular recognition by a CDC.

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Year:  2004        PMID： 15543155     DOI： 10.1038/nsmb862

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  107 in total

1.  Apicomplexan perforin-like proteins.

Authors:  Björn F C Kafsack; Vern B Carruthers
Journal:  Commun Integr Biol       Date:  2010-01

Review 2.  Membrane assembly of the cholesterol-dependent cytolysin pore complex.

Authors:  Eileen M Hotze; Rodney K Tweten
Journal:  Biochim Biophys Acta       Date:  2011-07-31

3.  Removal of the tag from His-tagged ILYd4, a human CD59 inhibitor, significantly improves its physical properties and its activity.

Authors:  Lin Wu; Sanbao Su; Fengming Liu; Tao Xu; Xiaoxiao Wang; Yan Huang; Xinlu Sun; Xiaowen Ge; Ting Chen; Huixia Liu; Chun Wang; Michael Chorev; Ting Xu; Xuebin Qin
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

Review 4.  Pore-forming toxins: ancient, but never really out of fashion.

Authors:  Matteo Dal Peraro; F Gisou van der Goot
Journal:  Nat Rev Microbiol       Date:  2015-12-07       Impact factor: 60.633

Review 5.  Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins.

Authors:  Rodney K Tweten
Journal:  Infect Immun       Date:  2005-10       Impact factor: 3.441

6.  Streptococcus agalactiae CAMP factor binds to GPI-anchored proteins.

Authors:  Shenhui Lang; Jie Xue; Zhongwu Guo; Michael Palmer
Journal:  Med Microbiol Immunol       Date:  2006-06-14       Impact factor: 3.402

7.  Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin.

Authors:  Casie E Soltani; Eileen M Hotze; Arthur E Johnson; Rodney K Tweten
Journal:  J Biol Chem       Date:  2007-04-05       Impact factor: 5.157

8.  Intermedilysin-receptor interactions during assembly of the pore complex: assembly intermediates increase host cell susceptibility to complement-mediated lysis.

Authors:  Stephanie LaChapelle; Rodney K Tweten; Eileen M Hotze
Journal:  J Biol Chem       Date:  2009-03-16       Impact factor: 5.157

9.  Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding.

Authors:  John J Flanagan; Rodney K Tweten; Arthur E Johnson; Alejandro P Heuck
Journal:  Biochemistry       Date:  2009-05-12       Impact factor: 3.162

10.  A high-affinity inhibitor of human CD59 enhances complement-mediated virolysis of HIV-1: implications for treatment of HIV-1/AIDS.

Authors:  Weiguo Hu; Qigui Yu; Ningjie Hu; Daniel Byrd; Tohti Amet; Cecilia Shikuma; Bruce Shiramizu; Jose A Halperin; Xuebin Qin
Journal:  J Immunol       Date:  2009-12-02       Impact factor: 5.422
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