| Literature DB >> 15542207 |
Ghislaine Gallez-Hawkins1, Xiuli Li, Anne E Franck, Lia Thao, Simon F Lacey, Don J Diamond, John A Zaia.
Abstract
A prime-boost immunization regimen allowed the use of low titer, helper-free rAAV-pp65mII and rAAV-IE1 virus to elicit specific humoral and cellular responses to two important cytomegalovirus (CMV) antigens: the immediate-early 1 (IE-1) and pp65 proteins. Simultaneous immunization of both CMV proteins, using DNA vaccine priming followed by rAAV boost, induced antibody (Ab) response, CD8 lymphocytes with cytotoxic function, and detectible binding of the cognate peptide epitopes for human HLA A*0201 restriction using tetramer technology.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15542207 DOI： 10.1016/j.vaccine.2004.06.048
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641