| Literature DB >> 15541508 |
Abstract
One feature of addiction is the enhanced locomotor response known as behavioral sensitization that occurs with prolonged exposure to psychostimulants. In a recent study, Yao et al. have analyzed four distinct animal models that share this common phenotype. Evaluation of gene expression in the striatum reveals that postsynaptic density (PSD)-95, a synaptic scaffolding protein, is downregulated in each model, suggesting an essential role for this protein in addiction.Entities:
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Year: 2004 PMID： 15541508 DOI： 10.1016/j.tins.2004.09.002
Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837