| Literature DB >> 15541474 |
Yang Yang1, Seisho Takeuchi, Kunihiro Tsukasaki, Yasuaki Yamada, Tomoko Hata, Naoki Mori, Atsuki Fukushima, Hiromi Seo, H Phillip Koeffler, Hirokuni Taguchi.
Abstract
We investigated methylation status of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma (ATL). APC methylation was found in 15 of 31 (48%) primary samples, and 2 of 4 (50%) ATL cell lines. Methylation of the APC gene occurred more frequently in acute ATL (12/21) (57%) than chronic ATL (1/8) (13%) (P = 0.03). APC was not expressed in the APC-methylated ATL cell line ST1. Demethylation with 5-azacytidine treatment restored APC expression in the ST1 cell line. Our data show that hypermethylation of the APC gene is involved in the pathogenesis of ATL.Entities:
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Year: 2005 PMID： 15541474 DOI： 10.1016/j.leukres.2004.05.004
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156