| Literature DB >> 15541368 |
Susumu Minamisawa1, Jin Oshikawa, Hiroshi Takeshima, Masahiko Hoshijima, Yibin Wang, Kenneth R Chien, Yoshihiro Ishikawa, Rumiko Matsuoka.
Abstract
Functional coupling between the sarcolemmal membrane and the sarcoplasmic reticulum is based on distinct structures called junctional membrane complexes (JMCs). Recently, junctophilins are found to be responsible for normal formation of JMCs. In the present study, we found that junctophilin type 2 (JP-2), a unique isoform in the heart, was localized in caveolin-rich membranes, and that the expression of JP-2 was up-regulated during normal development and down-regulated in a hypertrophic or a dilated cardiomyopathic mouse model. The expression levels of JP-2 may be associated with the development of T-tubules and impaired Ca(2+)-induced Ca(2+) release in the heart.Entities:
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Year: 2004 PMID： 15541368 DOI： 10.1016/j.bbrc.2004.10.107
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575