Literature DB >> 15539762

Molecular mechanisms and drug development in aquaporin water channel diseases: molecular mechanism of water channel aquaporin-2 trafficking.

Yumi Noda1, Sei Sasaki.   

Abstract

Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. Besides the cAMP-mediated effect of vasopressin on AQP2 trafficking to the apical membrane, other signaling cascades also induce this sorting. Recently, AQP2-binding proteins that directly regulate this trafficking have been uncovered: SPA-1, a GTPase-activating protein (GAP) for Rap1, and cytoskeletal protein actin. This review summarizes recent advances related to the trafficking mechanism of AQP2 and its defect causing nephrogenic diabetes insipidus (NDI).

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Year:  2004        PMID： 15539762     DOI： 10.1254/jphs.fmj04004x2

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  8 in total

1.  Nephrogenic diabetes insipidus in mice caused by deleting COOH-terminal tail of aquaporin-2.

Authors:  Peijun P Shi; Xiao R Cao; Jing Qu; Ken A Volk; Patricia Kirby; Roger A Williamson; John B Stokes; Baoli Yang
Journal:  Am J Physiol Renal Physiol       Date:  2007-01-16

Review 2.  Dynamic regulation and dysregulation of the water channel aquaporin-2: a common cause of and promising therapeutic target for water balance disorders.

Authors:  Yumi Noda
Journal:  Clin Exp Nephrol       Date:  2013-10-16       Impact factor: 2.801

3.  PKA phosphorylation of HERG protein regulates the rate of channel synthesis.

Authors:  Jian Chen; Jakub Sroubek; Yamini Krishnan; Yan Li; Jinsong Bian; Thomas V McDonald
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-02-20       Impact factor: 4.733

4.  Long-term growth of children with nephrogenic diabetes insipidus.

Authors:  Horacio Lejarraga; Maria Gracia Caletti; Silvia Caino; Alejandra Jiménez
Journal:  Pediatr Nephrol       Date:  2008-06-27       Impact factor: 3.714

5.  Use of LC-MS/MS and Bayes' theorem to identify protein kinases that phosphorylate aquaporin-2 at Ser256.

Authors:  Davis Bradford; Viswanathan Raghuram; Justin L L Wilson; Chung-Lin Chou; Jason D Hoffert; Mark A Knepper; Trairak Pisitkun
Journal:  Am J Physiol Cell Physiol       Date:  2014-03-05       Impact factor: 4.249

6.  Aquaporin-1 translocation and degradation mediates the water transportation mechanism of acetazolamide.

Authors:  Jianzhao Zhang; Yu An; Junwei Gao; Jing Han; Xueyang Pan; Yan Pan; Lu Tie; Xuejun Li
Journal:  PLoS One       Date:  2012-09-21       Impact factor: 3.240

Review 7.  Updates and Perspectives on Aquaporin-2 and Water Balance Disorders.

Authors:  Yumi Noda; Sei Sasaki
Journal:  Int J Mol Sci       Date:  2021-11-30       Impact factor: 5.923

8.  Aquaporin 5 Plays a Role in Estrogen-Induced Ectopic Implantation of Endometrial Stromal Cells in Endometriosis.

Authors:  Xiu Xiu Jiang; Xiang Wei Fei; Li Zhao; Xiao Lei Ye; Liao Bin Xin; Yang Qu; Kai Hong Xu; Rui Jin Wu; Jun Lin
Journal:  PLoS One       Date:  2015-12-17       Impact factor: 3.240
  8 in total

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