Literature DB >> 15539109

Brd4: tethering, segregation and beyond.

Alison A McBride1, Maria G McPhillips, Jaquelline G Oliveira.   

Abstract

Papillomaviruses segregate their genomes in dividing cells by tethering them to mitotic chromosomes via the viral E2 protein. A recent report has shown that this interaction is mediated by the cellular bromodomain protein Brd4. This discovery provides new insight into the mechanism of viral genome segregation and raises many exciting questions about the regulation and nature of the interaction of this complex with mitotic chromosomes.

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Year:  2004        PMID： 15539109     DOI： 10.1016/j.tim.2004.10.002

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  26 in total

1.  Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle.

Authors:  Michael R Evans; Claire D James; Molly L Bristol; Tara J Nulton; Xu Wang; Namsimar Kaur; Elizabeth A White; Brad Windle; Iain M Morgan
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

2.  Interaction of the papillomavirus E8--E2C protein with the cellular CHD6 protein contributes to transcriptional repression.

Authors:  Jasmin Fertey; Ingo Ammermann; Michael Winkler; Reinhard Stöger; Thomas Iftner; Frank Stubenrauch
Journal:  J Virol       Date:  2010-07-14       Impact factor: 5.103

3.  Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction.

Authors:  Brandon L Crowe; Ross C Larue; Chunhua Yuan; Sonja Hess; Mamuka Kvaratskhelia; Mark P Foster
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

4.  Brd4 links chromatin targeting to HPV transcriptional silencing.

Authors:  Shwu-Yuan Wu; A-Young Lee; Samuel Y Hou; Jongsook Kim Kemper; Hediye Erdjument-Bromage; Paul Tempst; Cheng-Ming Chiang
Journal:  Genes Dev       Date:  2006-08-18       Impact factor: 11.361

5.  BET Inhibition Attenuates Helicobacter pylori-Induced Inflammatory Response by Suppressing Inflammatory Gene Transcription and Enhancer Activation.

Authors:  Jinjing Chen; Zhen Wang; Xiangming Hu; Ruichuan Chen; Judith Romero-Gallo; Richard M Peek; Lin-Feng Chen
Journal:  J Immunol       Date:  2016-04-15       Impact factor: 5.422

6.  Analysis of cis-elements that facilitate extrachromosomal persistence of human papillomavirus genomes.

Authors:  Daraporn Pittayakhajonwut; Peter C Angeletti
Journal:  Virology       Date:  2008-02-14       Impact factor: 3.616

Review 7.  Papillomavirus interaction with cellular chromatin.

Authors:  Jianxin You
Journal:  Biochim Biophys Acta       Date:  2009-09-26

8.  Abrogation of the Brd4-positive transcription elongation factor B complex by papillomavirus E2 protein contributes to viral oncogene repression.

Authors:  Junpeng Yan; Qing Li; Sam Lievens; Jan Tavernier; Jianxin You
Journal:  J Virol       Date:  2010-01       Impact factor: 5.103

9.  Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movement.

Authors:  Elaine J Gauson; Xu Wang; Edward S Dornan; Pawel Herzyk; Molly Bristol; Iain M Morgan
Journal:  Virus Res       Date:  2015-09-10       Impact factor: 3.303

Review 10.  Recent advances in the search for antiviral agents against human papillomaviruses.

Authors:  Amélie Fradet-Turcotte; Jacques Archambault
Journal:  Antivir Ther       Date:  2007
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