Literature DB >> 15537823

Ligand discovery using small molecule microarrays.

Xuezhong G He1, Guillermo Gerona-Navarro, Samie R Jaffrey.   

Abstract

Small molecule microarrays have recently been used to identify ligands for several proteins, and several themes regarding screening strategies and limitations have emerged. In this review, some of the technical issues related to the manufacture and screening of small molecule microarrays, as well as prospects for small molecule microarrays in several areas of drug discovery and chemistry, are discussed.

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Year:  2004        PMID： 15537823     DOI： 10.1124/jpet.104.076943

Source DB:  PubMed          Journal:  J Pharmacol Exp Ther        ISSN： 0022-3565            Impact factor:   4.030


  6 in total

1.  Screening carbohydrate libraries for protein interactions using the direct ESI-MS assay. Applications to libraries of unknown concentration.

Authors:  Elena N Kitova; Amr El-Hawiet; John S Klassen
Journal:  J Am Soc Mass Spectrom       Date:  2014-08-19       Impact factor: 3.109

2.  Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay.

Authors:  Malathy Krishnamurthy; Nicole T Schirle; Peter A Beal
Journal:  Bioorg Med Chem       Date:  2008-08-29       Impact factor: 3.641

Review 3.  Chemical microarray: a new tool for drug screening and discovery.

Authors:  Haiching Ma; Kurumi Y Horiuchi
Journal:  Drug Discov Today       Date:  2006-07       Impact factor: 7.851

4.  A quantitative, high-throughput method identifies protein-glycan interactions via mass spectrometry.

Authors:  Pavel I Kitov; Elena N Kitova; Ling Han; Zhixiong Li; Jaesoo Jung; Emily Rodrigues; Carmanah D Hunter; Christopher W Cairo; Matthew S Macauley; John S Klassen
Journal:  Commun Biol       Date:  2019-07-22

5.  Developing an Efficient and General Strategy for Immobilization of Small Molecules onto Microarrays Using Isocyanate Chemistry.

Authors:  Chenggang Zhu; Xiangdong Zhu; James P Landry; Zhaomeng Cui; Quanfu Li; Yongjun Dang; Lan Mi; Fengyun Zheng; Yiyan Fei
Journal:  Sensors (Basel)       Date:  2016-03-16       Impact factor: 3.576

6.  Facile Synthesis of a Next Generation Safety-Catch Acid-Labile Linker, SCAL-2, Suitable for Solid-Phase Synthesis, On-Support Display and for Post-Synthesis Tagging.

Authors:  Christophe Portal; Martin Hintersteiner; Olivier Barbeau; Peter Dodd; Margaret Huggett; Irene Pérez-Pi; David Evans; Manfred Auer
Journal:  ChemistrySelect       Date:  2017-08-16       Impact factor: 2.109
  6 in total

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