Literature DB >> 15537340

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.

Eva Altmann1, Sandra W Cowan-Jacob, Martin Missbach.   

Abstract

Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.

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Year:  2004        PMID： 15537340     DOI： 10.1021/jm0493111

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  9 in total

1.  Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.

Authors:  Bryan T Mott; Rafaela S Ferreira; Anton Simeonov; Ajit Jadhav; Kenny Kean-Hooi Ang; William Leister; Min Shen; Julia T Silveira; Patricia S Doyle; Michelle R Arkin; James H McKerrow; James Inglese; Christopher P Austin; Craig J Thomas; Brian K Shoichet; David J Maloney
Journal:  J Med Chem       Date:  2010-01-14       Impact factor: 7.446

2.  Antimalarial activity of thiosemicarbazones and purine derived nitriles.

Authors:  Jeremy P Mallari; Wendyam A Guiguemde; R Kiplin Guy
Journal:  Bioorg Med Chem Lett       Date:  2009-05-05       Impact factor: 2.823

3.  Structure-guided development of selective TbcatB inhibitors.

Authors:  Jeremy P Mallari; Anang A Shelat; Aaron Kosinski; Conor R Caffrey; Michele Connelly; Fangyi Zhu; James H McKerrow; R Kiplin Guy
Journal:  J Med Chem       Date:  2009-10-22       Impact factor: 7.446

4.  Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.

Authors:  Jeffery D Zwicker; David Smith; Alfredo J Guerra; Jacob R Hitchens; Nicole Haug; Steve Vander Roest; Pil Lee; Bo Wen; Duxin Sun; Lu Wang; Richard F Keep; Jianming Xiang; Vern B Carruthers; Scott D Larsen
Journal:  ACS Chem Neurosci       Date:  2020-02-18       Impact factor: 4.418

5.  Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety.

Authors:  Bojana Mirković; Izidor Sosič; Stanislav Gobec; Janko Kos
Journal:  PLoS One       Date:  2011-11-04       Impact factor: 3.240

6.  Cysteine protease inhibition by nitrile-based inhibitors: a computational study.

Authors:  Matthew G Quesne; Richard A Ward; Sam P de Visser
Journal:  Front Chem       Date:  2013-12-27       Impact factor: 5.221

7.  Natural Products as New Treatment Options for Trichomoniasis: A Molecular Docking Investigation.

Authors:  Mary Snow Setzer; Kendall G Byler; Ifedayo Victor Ogungbe; William N Setzer
Journal:  Sci Pharm       Date:  2017-01-27

8.  1-[(3-Benz-yloxy-2-nitro-phen-oxy)meth-yl]benzene.

Authors:  Hoong-Kun Fun; Suhana Arshad; S R Ubaradka; Prakash Shetty; Arun M Isloor
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-07-04

9.  Crystal structure of bis[4-(di-methyl-amino)-pyridinium] bis(2-nitro-benzoate) trihydrate.

Authors:  N Sivakumar; S Muralidharan; G Chakkaravarthi; D Velmurugan; G Anbalagan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-09-20
  9 in total

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