| Literature DB >> 15535677 |
Antonio Ramírez1, John Candler, Crystal G Bashore, Michael C Wirtz, Jotham W Coe, David B Collum.
Abstract
The key elimination step for the formation of 3-chloro- and 3-fluorobenzyne from 2-chloro-6-fluorophenyllithium displays a pronounced solvent-dependent regioselectivity. 6Li and 13C NMR spectroscopic studies on 2-chloro-6-fluorophenyllithium reveal a single monomeric aryllithium, suggested by DFT computational studies to be a trisolvate. Rate studies indicate that the elimination of LiCl and LiF proceeds via trisolvated and disolvated monomers, respectively.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15535677 DOI： 10.1021/ja044899m
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419