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Literature DB >> 15534261

Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial.

Kristine Yaffe¹, Traci E Clemons, Wendy L McBee, Anne S Lindblad.

Abstract

Participants in the Age-Related Eye Disease Study were randomly assigned to receive daily antioxidants (vitamin C, 500 mg; vitamin E, 400 IU; beta carotene, 15 mg), zinc and copper (zinc, 80 mg; cupric oxide, 2 mg), antioxidants plus zinc and copper, or placebo. A cognitive battery was administered to 2,166 elderly persons after a median of 6.9 years of treatment. Treatment groups did not differ on any of the six cognitive tests (p > 0.05 for all). These results do not support a beneficial or harmful effect of antioxidants or zinc and copper on cognition in older adults.

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Year: 2004 PMID： 15534261 PMCID： PMC1473037 DOI： 10.1212/01.wnl.0000142969.19465.8f

Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910

10 in total

1. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men.

Authors: K H Masaki; K G Losonczy; G Izmirlian; D J Foley; G W Ross; H Petrovitch; R Havlik; L R White
Journal: Neurology Date: 2000-03-28 Impact factor: 9.910

2. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.

Authors:
Journal: Arch Ophthalmol Date: 2001-10

3. Antioxidant vitamin intake and risk of Alzheimer disease.

Authors: Jose A Luchsinger; Ming-Xin Tang; Steven Shea; Richard Mayeux
Journal: Arch Neurol Date: 2003-02

4. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

Authors: M Sano; C Ernesto; R G Thomas; M R Klauber; K Schafer; M Grundman; P Woodbury; J Growdon; C W Cotman; E Pfeiffer; L S Schneider; L J Thal
Journal: N Engl J Med Date: 1997-04-24 Impact factor: 91.245

5. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study.

Authors: Peter P Zandi; James C Anthony; Ara S Khachaturian; Stephanie V Stone; Deborah Gustafson; JoAnn T Tschanz; Maria C Norton; Kathleen A Welsh-Bohmer; John C S Breitner
Journal: Arch Neurol Date: 2004-01

6. Dietary intake of antioxidants and risk of Alzheimer disease.

Authors: Marianne J Engelhart; Mirjam I Geerlings; Annemieke Ruitenberg; John C van Swieten; Albert Hofman; Jacqueline C M Witteman; Monique M B Breteler
Journal: JAMA Date: 2002-06-26 Impact factor: 56.272

7. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study.

Authors: Martha Clare Morris; Denis A Evans; Julia L Bienias; Christine C Tangney; David A Bennett; Neelum Aggarwal; Robert S Wilson; Paul A Scherr
Journal: JAMA Date: 2002-06-26 Impact factor: 56.272

8. Elevation of serum copper levels in Alzheimer's disease.

Authors: R Squitti; D Lupoi; P Pasqualetti; G Dal Forno; F Vernieri; P Chiovenda; L Rossi; M Cortesi; E Cassetta; P M Rossini
Journal: Neurology Date: 2002-10-22 Impact factor: 9.910

9. Rapid induction of Alzheimer A beta amyloid formation by zinc.

Authors: A I Bush; W H Pettingell; G Multhaup; M d Paradis; J P Vonsattel; J F Gusella; K Beyreuther; C L Masters; R E Tanzi
Journal: Science Date: 1994-09-02 Impact factor: 47.728

10. Use of antioxidant supplements and its association with cognitive function in a rural elderly cohort: the MoVIES Project. Monongahela Valley Independent Elders Survey.

Authors: A B Mendelsohn; S H Belle; G P Stoehr; M Ganguli
Journal: Am J Epidemiol Date: 1998-07-01 Impact factor: 4.897

10 in total

42 in total

Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial.

1. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men.

2. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.

3. Antioxidant vitamin intake and risk of Alzheimer disease.

4. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

5. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study.

6. Dietary intake of antioxidants and risk of Alzheimer disease.

7. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study.

8. Elevation of serum copper levels in Alzheimer's disease.

9. Rapid induction of Alzheimer A beta amyloid formation by zinc.

10. Use of antioxidant supplements and its association with cognitive function in a rural elderly cohort: the MoVIES Project. Monongahela Valley Independent Elders Survey.

Review 1. Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease.

Review 2. Therapeutic Strategies and Nano-Drug Delivery Applications in Management of Aging Alzheimer's Disease.

Review 3. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers.

Review 4. A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease.

5. Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation.

Review 6. Nutrition and neurodegeneration: epidemiological evidence and challenges for future research.

7. Summary results and recommendations from the age-related eye disease study.

8. The association of antioxidants and cognition in the Nurses' Health Study.

9. Lower fluid and fruits/vegetable intake in questionable dementia among older Hong Kong Chinese.

10. Plasma trace elements and cognitive function in older men and women: the Rancho Bernardo study.