| Literature DB >> 15533994 |
M Rentzos1, M Michalopoulou, C Nikolaou, C Cambouri, A Rombos, A Dimitrakopoulos, E Kapaki, D Vassilopoulos.
Abstract
Serum soluble intercellular adhesion molecule-1 (s-ICAM-1) and soluble E-selectin (s-ELAM-1) were evaluated in 25 patients with Alzheimer's disease (AD), 54 patients with noninflammatory neurological diseases (NIND), and 15 control subjects. Patients with AD had a higher s-ICAM-1 level compared with the NIND patients and the control subjects (P< .001 and P< .04, respectively). The presence of high s-ICAM-1 values may be related to immunological processes involved in pathogenetic mechanisms of AD. The not statistically significant values of (s-ELAM-1), a glycoprotein considered an exclusive marker of endothelial activation, compared with the NIND patients and healthy subjects (P< .47 and P< .17, respectively), seem to suggest the neural rather than the endothelial s-ICAM origin in patients with AD.Entities:
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Year: 2004 PMID： 15533994 DOI： 10.1177/0891988704269822
Source DB: PubMed Journal: J Geriatr Psychiatry Neurol ISSN： 0891-9887 Impact factor: 2.680