BACKGROUND: The prognostic value of left ventricular (LV) concentric remodeling in essential hypertension, and particularly in uncomplicated mild hypertension, is not yet completely clear. We investigated cardiovascular outcome in uncomplicated mild hypertensive patients with normal LV geometry and LV concentric remodeling. METHODS: The occurrence of fatal and nonfatal cardiovascular events was evaluated in 1088 uncomplicated mild hypertensive patients, 751 with normal LV geometry (LV mass index <125 g/m(2) in men and <110 g/m(2) in women and relative wall thickness <0.45) and 337 with LV concentric remodeling (LV mass index <125 g/m(2) in men and <110 g/m(2) in women and relative wall thickness >/=0.45). RESULTS: During follow-up (4.74 +/- 2.4 years, range 0.5 to 9.7 years) the event rates per 100 patient-years in subjects with normal LV geometry and LV concentric remodeling were 0.69 and 1.87, respectively. After adjustment for other covariates, Cox regression analysis showed that LV concentric remodeling (LV concentric remodeling versus normal LV geometry, RR 1.78, 95% CI 1.02 to 3.1, P < .05) was an independent predictor of cardiovascular events. CONCLUSION: In a population with uncomplicated mild hypertension, patients with LV concentric remodeling have a worse prognosis than those with normal LV geometry.
BACKGROUND: The prognostic value of left ventricular (LV) concentric remodeling in essential hypertension, and particularly in uncomplicated mild hypertension, is not yet completely clear. We investigated cardiovascular outcome in uncomplicated mild hypertensivepatients with normal LV geometry and LV concentric remodeling. METHODS: The occurrence of fatal and nonfatal cardiovascular events was evaluated in 1088 uncomplicated mild hypertensivepatients, 751 with normal LV geometry (LV mass index <125 g/m(2) in men and <110 g/m(2) in women and relative wall thickness <0.45) and 337 with LV concentric remodeling (LV mass index <125 g/m(2) in men and <110 g/m(2) in women and relative wall thickness >/=0.45). RESULTS: During follow-up (4.74 +/- 2.4 years, range 0.5 to 9.7 years) the event rates per 100 patient-years in subjects with normal LV geometry and LV concentric remodeling were 0.69 and 1.87, respectively. After adjustment for other covariates, Cox regression analysis showed that LV concentric remodeling (LV concentric remodeling versus normal LV geometry, RR 1.78, 95% CI 1.02 to 3.1, P < .05) was an independent predictor of cardiovascular events. CONCLUSION: In a population with uncomplicated mild hypertension, patients with LV concentric remodeling have a worse prognosis than those with normal LV geometry.
Authors: Krati Chauhan; Richard B Devereux; Dc Rao; Ulrich Broeckel; Charles C Gu; Paul Hopkins; Donna K Arnett Journal: Int J Mol Epidemiol Genet Date: 2010-02-26
Authors: Seong-Mi Park; Janet Wei; Galen Cook-Wiens; Michael D Nelson; Louise Thomson; Daniel Berman; Eileen Handberg; John Petersen; David Anderson; Carl J Pepine; C Noel Bairey Merz Journal: Eur Heart J Cardiovasc Imaging Date: 2019-08-01 Impact factor: 6.875
Authors: Aditya Jain; Robyn L McClelland; Joseph F Polak; Steven Shea; Gregory L Burke; Diane E Bild; Karol E Watson; Matthew J Budoff; Kiang Liu; Wendy S Post; Aaron R Folsom; João A C Lima; David A Bluemke Journal: Circ Cardiovasc Imaging Date: 2010-11-10 Impact factor: 7.792
Authors: Herman A Taylor; Alan D Penman; Hui Han; Abiola Dele-Michael; Thomas N Skelton; Ervin R Fox; Emelia J Benjamin; Donna K Arnett; Thomas H Mosley Journal: Am J Cardiol Date: 2007-04-10 Impact factor: 2.778
Authors: Quynh A Truong; Michael Toepker; Amir A Mahabadi; Fabian Bamberg; Ian S Rogers; Ron Blankstein; Thomas J Brady; John T Nagurney; Udo Hoffmann Journal: J Hypertens Date: 2009-12 Impact factor: 4.844
Authors: David A Bluemke; Richard A Kronmal; João A C Lima; Kiang Liu; Jean Olson; Gregory L Burke; Aaron R Folsom Journal: J Am Coll Cardiol Date: 2008-12-16 Impact factor: 24.094
Authors: Lawreen H Connors; Flora Sam; Martha Skinner; Francesco Salinaro; Fangui Sun; Frederick L Ruberg; John L Berk; David C Seldin Journal: Circulation Date: 2015-12-11 Impact factor: 29.690