OBJECTIVE: To determine the heritability of age at natural menopause from mother-daughter pairs. DESIGN: Two-generation families were selected to study heritability of menopausal age. SETTING: Subjects were drawn from a population-based study. PATIENT(S): One hundred sixty-four mother-daughter pairs with a natural menopausal age. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The heritability of age at natural menopause estimated by a random-effects model. RESULT(S): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. CONCLUSION(S): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed.
OBJECTIVE: To determine the heritability of age at natural menopause from mother-daughter pairs. DESIGN: Two-generation families were selected to study heritability of menopausal age. SETTING: Subjects were drawn from a population-based study. PATIENT(S): One hundred sixty-four mother-daughter pairs with a natural menopausal age. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The heritability of age at natural menopause estimated by a random-effects model. RESULT(S): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. CONCLUSION(S): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed.
Authors: Marinus J C Eijkemans; Frans van Poppel; Dik F Habbema; Ken R Smith; Henri Leridon; Egbert R te Velde Journal: Hum Reprod Date: 2014-03-27 Impact factor: 6.918
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