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Literature DB >> 15532728

Morphogenetic and apoptotic changes in diabetic cataract: prevention by pyruvate.

Abstract

Studies have been conducted to ascertain the preventive effect of pyruvate against diabetes induced damage to DNA and associated morphogenetic changes in the mouse lens. Such changes were characterized by DNA nicks as well as by gross morphological changes in the nuclei, evident respectively by TUNEL and Hoechst staining procedures. Morphogenetic changes were also apparent by abnormal diferentiation of the germinal epithelial cells and errors in their migratory pathway. These changes were prevented by simultaneous administration of pyruvate to the diabetic animals. The preventive effect of this agent is attributable to its property of scavenging oxy-radicals generated by high levels of the sugars.

Entities: Chemical Disease Species

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Year: 2004 PMID： 15532728 DOI： 10.1023/b:mcbi.0000038220.47170.d0

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

12 in total

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Authors: K R Hegde; M G Henein; S D Varma
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11 in total

1. Risk factors for incident cortical, nuclear, posterior subcapsular, and mixed lens opacities: the Los Angeles Latino eye study.

Authors: Grace M Richter; Farzana Choudhury; Mina Torres; Stanley P Azen; Rohit Varma
Journal: Ophthalmology Date: 2012-07-06 Impact factor: 12.079

Review 2. Role of ultraviolet irradiation and oxidative stress in cataract formation-medical prevention by nutritional antioxidants and metabolic agonists.

Authors: Shambhu D Varma; Svitlana Kovtun; Kavita R Hegde
Journal: Eye Contact Lens Date: 2011-07 Impact factor: 2.018

Morphogenetic and apoptotic changes in diabetic cataract: prevention by pyruvate.

Review 1. Vitamins C and E in cataract risk reduction.

2. Senile cataract extraction and diabetes.

3. Cataract extraction and diabetes.

4. Diabetes-induced biochemical changes in rat lens: attenuation of cataractogenesis by pyruvate.

5. Allopurinol promotes and butylated hydroxy toluene prevents sugar-induced cataractogenesis.

6. Light-induced damage to ocular lens cation pump: prevention by vitamin C.

Review 7. Oxidative stress on lens and cataract formation: role of light and oxygen.

8. Establishment of the mouse as a model animal for the study of diabetic cataracts.

9. Establishment of mouse as an animal model for study of diabetic cataracts: biochemical studies.

10. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1. Risk factors for incident cortical, nuclear, posterior subcapsular, and mixed lens opacities: the Los Angeles Latino eye study.

Review 2. Role of ultraviolet irradiation and oxidative stress in cataract formation-medical prevention by nutritional antioxidants and metabolic agonists.

3. Prevention of oxidative damage to lens by caffeine.

4. Prevention of cataract by pyruvate in experimentally diabetic mice.

5. High sugar-induced repression of antioxidant and anti-apoptotic genes in lens: reversal by pyruvate.

6. Diabetic cataract-pathogenesis, epidemiology and treatment.

7. Effect of high sugar levels on miRNA expression. Studies with galactosemic mice lenses.

8. Effectiveness of topical caffeine in cataract prevention: studies with galactose cataract.

9. Prevention of cataract in diabetic mice by topical pyruvate.

10. Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells.