Literature DB >> 1553258

The effects of thapsigargin on [Ca2+]i in isolated rat mesenteric artery vascular smooth muscle cells.

I Baró1, D A Eisner.   

Abstract

The effects of thapsigargin were studied on single cells isolated from side branches of the rat mesenteric artery. Thapsigargin (150 nM) produced a transient increase of [Ca2+]i. This transient rise of [Ca2+]i was unaffected by removing external Ca2+ ions. This suggests that thapsigargin is releasing Ca2+ ions from an intracellular store. In the absence of thapsigargin both noradrenaline and caffeine also produced a transient increase of [Ca2+]i. These increases were abolished by prior exposure to thapsigargin. Correspondingly, the effects of thapsigargin were abolished by prior exposure to caffeine. These results show that thapsigargin releases Ca2+ from the noradrenaline and caffeine-sensitive stores.

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Year:  1992        PMID： 1553258     DOI： 10.1007/bf00378652

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  10 in total

Review 1.  Cellular mechanisms regulating [Ca2+]i smooth muscle.

Authors:  C van Breemen; K Saida
Journal:  Annu Rev Physiol       Date:  1989       Impact factor: 19.318

2.  The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations.

Authors:  O Thastrup; H Linnebjerg; P J Bjerrum; J B Knudsen; S B Christensen
Journal:  Biochim Biophys Acta       Date:  1987-01-19

3.  [Ca2+]i and contraction of ear artery in response to rapid stimulation by NE: measurements with quin2 and fura-2.

Authors:  M Vonderlage; V Schreiner
Journal:  Am J Physiol       Date:  1989-08

4.  Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2.

Authors:  K Sato; H Ozaki; H Karaki
Journal:  J Pharmacol Exp Ther       Date:  1988-07       Impact factor: 4.030

5.  The role of [Ca2+]i and [Ca2+] sensitization in the caffeine contracture of rat myocytes: measurement of [Ca2+]i and [caffeine]i.

Authors:  S C O'Neill; P Donoso; D A Eisner
Journal:  J Physiol       Date:  1990-06       Impact factor: 5.182

6.  Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

Authors:  O Thastrup; P J Cullen; B K Drøbak; M R Hanley; A P Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

7.  Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane.

Authors:  H Takemura; A R Hughes; O Thastrup; J W Putney
Journal:  J Biol Chem       Date:  1989-07-25       Impact factor: 5.157

8.  A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells.

Authors:  T R Jackson; S I Patterson; O Thastrup; M R Hanley
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857

9.  Effects of MeCh, thapsigargin, and La3+ on plasmalemmal and intracellular Ca2+ transport in lacrimal acinar cells.

Authors:  C Y Kwan; H Takemura; J F Obie; O Thastrup; J W Putney
Journal:  Am J Physiol       Date:  1990-06

10.  Effects of thapsigargin in isolated rat thoracic aorta.

Authors:  E O Mikkelsen; O Thastrup; S B Christensen
Journal:  Pharmacol Toxicol       Date:  1988-01
  10 in total
  11 in total

1.  The effect of cyclopiazonic acid on excitation-contraction coupling in guinea-pig ureteric smooth muscle: role of the sarcoplasmic reticulum.

Authors:  T V Burdyga; S Wray
Journal:  J Physiol       Date:  1999-06-15       Impact factor: 5.182

2.  An investigation of intrinsic buffering power in rat vascular smooth muscle cells.

Authors:  C Austin; S Wray
Journal:  Pflugers Arch       Date:  1995-01       Impact factor: 3.657

3.  Changes of intracellular [Ca2+] during refilling of sarcoplasmic reticulum in rat ventricular and vascular smooth muscle.

Authors:  I Baró; S C O'Neill; D A Eisner
Journal:  J Physiol       Date:  1993-06       Impact factor: 5.182

4.  Extracellular pH signals affect rat vascular tone by rapid transduction into intracellular pH changes.

Authors:  C Austin; S Wray
Journal:  J Physiol       Date:  1993-07       Impact factor: 5.182

5.  Functionally and spatially distinct Ca2+ stores are revealed in cultured vascular smooth muscle cells.

Authors:  R M Tribe; M L Borin; M P Blaustein
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

6.  Relationship between NaF- and thapsigargin-induced endothelium-dependent hyperpolarization in rat mesenteric artery.

Authors:  M Fukao; Y Hattori; A Sato; M Y Liu; H Watanabe; T Q Kim; M Kanno
Journal:  Br J Pharmacol       Date:  1999-04       Impact factor: 8.739

7.  Regulation of mesangial cell ion channels by insulin and angiotensin II. Possible role in diabetic glomerular hyperfiltration.

Authors:  B N Ling; E E Seal; D C Eaton
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

8.  Factors controlling changes in intracellular Ca2+ concentration produced by noradrenaline in rat mesenteric artery smooth muscle cells.

Authors:  I Baró; D A Eisner
Journal:  J Physiol       Date:  1995-01-15       Impact factor: 5.182

9.  Effects of cyclopiazonic acid and thapsigargin on electromechanical activities and intracellular Ca2+ in smooth muscle of carotid artery of hypertensive rats.

Authors:  F Sekiguchi; K Shimamura; M Akashi; S Sunano
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

10.  Crosstalk between ryanodine receptors and IP(3) receptors as a factor shaping spontaneous Ca(2+)-release events in rabbit portal vein myocytes.

Authors:  D V Gordienko; T B Bolton
Journal:  J Physiol       Date:  2002-08-01       Impact factor: 5.182
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