Literature DB >> 15531772

Manipulating the type 1 vs type 2 balance in type 1 diabetes.

Urs Christen1, Matthias G von Herrath.   

Abstract

Virus infections cause a strong inflammatory reaction that is dominated by the expression of type 1 cytokines and chemokines. Such an aggressive immune response by the host is necessary to eliminate intracellular pathogens. However, because of this shift in the type 1 vs type 2 balance of the immune response, virus infections are potential candidates for triggering autoimmune diseases, such as type 1 diabetes (T1D), herpes stromal keratitis, or multiple sclerosis (MS). In this review we will focus on the pathogenesis of T1D in a virus-induced transgenic mouse model and discuss possibilities of how an aggressive type 1-dominated immune response can be restrained and autoimmunity be abrogated.

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Year:  2004        PMID： 15531772     DOI： 10.1385/IR:30:3:309

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  133 in total

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Review 4.  A new look at viruses in type 1 diabetes.

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Journal:  Transplantation       Date:  2000-03-27       Impact factor: 4.939

6.  Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

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Journal:  Cell       Date:  1991-04-19       Impact factor: 41.582

8.  More stringent conditions of plasmid DNA vaccination are required to protect grafted versus endogenous islets in nonobese diabetic mice.

Authors:  Christian Seifarth; Shannon Pop; Bo Liu; Carmen P Wong; Roland Tisch
Journal:  J Immunol       Date:  2003-07-01       Impact factor: 5.422

9.  Neutralization of IFN-inducible protein 10/CXCL10 exacerbates experimental autoimmune encephalomyelitis.

Authors:  Shosaku Narumi; Toshikatu Kaburaki; Hiroyuki Yoneyama; Hiroyuki Iwamura; Yuko Kobayashi; Kouji Matsushima
Journal:  Eur J Immunol       Date:  2002-06       Impact factor: 5.532

10.  Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

Authors:  S Guerder; D E Picarella; P S Linsley; R A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205
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  8 in total

Review 1.  CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm.

Authors:  Kiyoshi Hirahara; Toshinori Nakayama
Journal:  Int Immunol       Date:  2016-02-12       Impact factor: 4.823

Review 2.  The impact of anti-inflammatory cytokines on the pancreatic β-cell.

Authors:  M A Russell; N G Morgan
Journal:  Islets       Date:  2014       Impact factor: 2.694

3.  Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10.

Authors:  Melba Muñoz; Ahmed N Hegazy; Tobias M Brunner; Vivien Holecska; Roman M Marek; Anja Fröhlich; Max Löhning
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-09       Impact factor: 11.205

4.  Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 diabetes.

Authors:  M N Pham; H Kolb; T Battelino; J Ludvigsson; P Pozzilli; F Zivehe; M Roden; T Mandrup-Poulsen; N C Schloot
Journal:  Diabetologia       Date:  2013-03-15       Impact factor: 10.122

5.  The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells.

Authors:  Lie Wang; Kathryn F Wildt; Ehydel Castro; Yumei Xiong; Lionel Feigenbaum; Lino Tessarollo; Rémy Bosselut
Journal:  Immunity       Date:  2008-12-08       Impact factor: 31.745

6.  Immunomodulation of Autoimmune Arthritis by Herbal CAM.

Authors:  Shivaprasad H Venkatesha; Rajesh Rajaiah; Brian M Berman; Kamal D Moudgil
Journal:  Evid Based Complement Alternat Med       Date:  2010-12-22       Impact factor: 2.629

7.  Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs.

Authors:  Yuhong Yang; Amy E Lovett-Racke; Michael K Racke
Journal:  PPAR Res       Date:  2010-12-22       Impact factor: 4.964

8.  Radon Therapy for Autoimmune Diseases Pemphigus and Diabetes: 2 Case Reports.

Authors:  Shuji Kojima; Jerry M Cuttler; Noriko Shimura; Hironobu Koga; Akihisa Murata; Akira Kawashima
Journal:  Dose Response       Date:  2019-05-19       Impact factor: 2.658
  8 in total

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