Richard F Spaide1. 1. Vitreous-Retina-Macula Consultants of New York, New York, USA. VRMNY@aol.com
Abstract
PURPOSE: To evaluate the disease involvement in a patient with acute zonal occult outer retinopathy (AZOOR). DESIGN: Observational case report. METHODS: A patient with acute zonal occult outer retinopathy was imaged with fundus photography, fluorescein and indocyanine green angiography, and autofluorescence photography. RESULTS: There was subtle depigmentation in the central portion of the lesion with a drusen-like deposit at the outer border. Fluorescein angiography showed a transmission defect centrally and a blocking defect at the border where the drusenoid material accumulated. Autofluorescent photography demonstrated that the drusenoid material was intensely autofluorescent, consistent with the presence of lipofuscin, and the central portion of the lesion showed atrophy of the retinal pigment epithelium. Indocyanine green angiography showed atrophy of the choriocapillaris underlying areas of atrophy of the retinal pigment epithelium. CONCLUSIONS: In this case acute zonal occult outer retinopathy caused an area of retinal pigment epithelium cell death with lipofuscin-laden cells at the border of the expanding lesion and associated atrophy of the underlying choriocapillaris.
PURPOSE: To evaluate the disease involvement in a patient with acute zonal occult outer retinopathy (AZOOR). DESIGN: Observational case report. METHODS: A patient with acute zonal occult outer retinopathy was imaged with fundus photography, fluorescein and indocyanine green angiography, and autofluorescence photography. RESULTS: There was subtle depigmentation in the central portion of the lesion with a drusen-like deposit at the outer border. Fluorescein angiography showed a transmission defect centrally and a blocking defect at the border where the drusenoid material accumulated. Autofluorescent photography demonstrated that the drusenoid material was intensely autofluorescent, consistent with the presence of lipofuscin, and the central portion of the lesion showed atrophy of the retinal pigment epithelium. Indocyanine green angiography showed atrophy of the choriocapillaris underlying areas of atrophy of the retinal pigment epithelium. CONCLUSIONS: In this case acute zonal occult outer retinopathy caused an area of retinal pigment epithelium cell death with lipofuscin-laden cells at the border of the expanding lesion and associated atrophy of the underlying choriocapillaris.
Authors: Steven Yeh; Farzin Forooghian; Wai T Wong; Lisa J Faia; Catherine Cukras; Julie C Lew; Keith Wroblewski; Eric D Weichel; Catherine B Meyerle; Hatice Nida Sen; Emily Y Chew; Robert B Nussenblatt Journal: Arch Ophthalmol Date: 2010-01
Authors: Robert A Sisk; Robert B Hufnagel; Ailee Laham; Elizabeth S Wohler; Nara Sobreira; Zubair M Ahmed Journal: J Ophthalmol Date: 2018-07-11 Impact factor: 1.909
Authors: Ugo Introini; Giuseppe Casalino; Elona Dhrami-Gavazi; Sri Krishna Mukkamala; Sarah Mrejen; Hermann Schubert; Salomon Y Cohen; Claudio Azzolini; Francesco Bandello; Stanley Chang; Lawrence A Yannuzzi Journal: Int J Retina Vitreous Date: 2018-08-29