Literature DB >> 15530777

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration.

Rammohan V Rao1, Dale E Bredesen.   

Abstract

The accumulation of misfolded proteins (e.g. mutant or damaged proteins) triggers cellular stress responses that protect cells against the toxic buildup of such proteins. However, prolonged stress due to the buildup of these toxic proteins induces specific death pathways. Dissecting these pathways should be valuable in understanding the pathogenesis of, and ultimately in designing therapy for, neurodegenerative diseases that feature misfolded proteins.

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Year:  2004        PMID： 15530777      PMCID： PMC3970707          DOI： 10.1016/j.ceb.2004.09.012

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  144 in total

1.  The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response.

Authors:  C Sidrauski; P Walter
Journal:  Cell       Date:  1997-09-19       Impact factor: 41.582

2.  Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response.

Authors:  T Kawahara; H Yanagi; T Yura; K Mori
Journal:  Mol Biol Cell       Date:  1997-10       Impact factor: 4.138

3.  Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

Authors:  J N Keller; Q Guo; F W Holtsberg; A J Bruce-Keller; M P Mattson
Journal:  J Neurosci       Date:  1998-06-15       Impact factor: 6.167

4.  Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.

Authors:  R Krüger; W Kuhn; T Müller; D Woitalla; M Graeber; S Kösel; H Przuntek; J T Epplen; L Schöls; O Riess
Journal:  Nat Genet       Date:  1998-02       Impact factor: 38.330

Review 5.  Caspases: intracellular signaling by proteolysis.

Authors:  G S Salvesen; V M Dixit
Journal:  Cell       Date:  1997-11-14       Impact factor: 41.582

6.  Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.

Authors:  D Martindale; A Hackam; A Wieczorek; L Ellerby; C Wellington; K McCutcheon; R Singaraja; P Kazemi-Esfarjani; R Devon; S U Kim; D E Bredesen; F Tufaro; M R Hayden
Journal:  Nat Genet       Date:  1998-02       Impact factor: 38.330

7.  Bcl-XL cooperatively associates with the Bap31 complex in the endoplasmic reticulum, dependent on procaspase-8 and Ced-4 adaptor.

Authors:  F W Ng; G C Shore
Journal:  J Biol Chem       Date:  1998-02-06       Impact factor: 5.157

8.  Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion.

Authors:  J K White; W Auerbach; M P Duyao; J P Vonsattel; J F Gusella; A L Joyner; M E MacDonald
Journal:  Nat Genet       Date:  1997-12       Impact factor: 38.330

9.  CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum.

Authors:  H Zinszner; M Kuroda; X Wang; N Batchvarova; R T Lightfoot; H Remotti; J L Stevens; D Ron
Journal:  Genes Dev       Date:  1998-04-01       Impact factor: 11.361

10.  Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

Authors:  J M Warrick; H L Paulson; G L Gray-Board; Q T Bui; K H Fischbeck; R N Pittman; N M Bonini
Journal:  Cell       Date:  1998-06-12       Impact factor: 41.582
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  134 in total

1.  Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury.

Authors:  Maryla Krajewska; Lucy Xu; Wenjie Xu; Stan Krajewski; Christina L Kress; Jiankun Cui; Li Yang; Fumitoshi Irie; Yu Yamaguchi; Stuart A Lipton; John C Reed
Journal:  Brain Res       Date:  2010-11-12       Impact factor: 3.252

Review 2.  Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases.

Authors:  Zezong Gu; Tomohiro Nakamura; Stuart A Lipton
Journal:  Mol Neurobiol       Date:  2010-03-25       Impact factor: 5.590

Review 3.  Endoplasmic reticulum stress: cell life and death decisions.

Authors:  Chunyan Xu; Beatrice Bailly-Maitre; John C Reed
Journal:  J Clin Invest       Date:  2005-10       Impact factor: 14.808

4.  Coupling endoplasmic reticulum stress to the cell-death program: a novel HSP90-independent role for the small chaperone protein p23.

Authors:  R V Rao; K Niazi; P Mollahan; X Mao; D Crippen; K S Poksay; S Chen; D E Bredesen
Journal:  Cell Death Differ       Date:  2006-03       Impact factor: 15.828

Review 5.  Cell death in the nervous system.

Authors:  Dale E Bredesen; Rammohan V Rao; Patrick Mehlen
Journal:  Nature       Date:  2006-10-19       Impact factor: 49.962

6.  Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice.

Authors:  Yosuke Yamada; Utano Tomaru; Akihiro Ishizu; Tomoki Ito; Takayuki Kiuchi; Ayako Ono; Syota Miyajima; Katsura Nagai; Tsunehito Higashi; Yoshihiro Matsuno; Hirotoshi Dosaka-Akita; Masaharu Nishimura; Soichi Miwa; Masanori Kasahara
Journal:  Lab Invest       Date:  2015-04-27       Impact factor: 5.662

7.  Potential effect of S-nitrosylated protein disulfide isomerase on mutant SOD1 aggregation and neuronal cell death in amyotrophic lateral sclerosis.

Authors:  Gye Sun Jeon; Tomohiro Nakamura; Jeong-Seon Lee; Won-Jun Choi; Suk-Won Ahn; Kwang-Woo Lee; Jung-Joon Sung; Stuart A Lipton
Journal:  Mol Neurobiol       Date:  2013-10-04       Impact factor: 5.590

8.  Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol.

Authors:  Shankar J Chinta; Karen S Poksay; Gaayatri Kaundinya; Matthew Hart; Dale E Bredesen; Julie K Andersen; Rammohan V Rao
Journal:  J Mol Neurosci       Date:  2009-01-15       Impact factor: 3.444

9.  Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.

Authors:  Danyelle M Townsend; Yefim Manevich; Lin He; Ying Xiong; Robert R Bowers; Steven Hutchens; Kenneth D Tew
Journal:  Cancer Res       Date:  2009-09-22       Impact factor: 12.701

10.  GIV/Girdin promotes cell survival during endoplasmic reticulum stress.

Authors:  Peter Nguyen; Rosanna Calderon; Yoanna Rodriguez-Ledezma; Kelly Araujo; Deepali Bhandari
Journal:  Mol Cell Biochem       Date:  2018-08-25       Impact factor: 3.396
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