Literature DB >> 15530492

A simple cellular automaton model for influenza A viral infections.

Catherine Beauchemin1, John Samuel, Jack Tuszynski.   

Abstract

Viral kinetics have been extensively studied in the past through the use of spatially homogeneous ordinary differential equations describing the time evolution of the diseased state. However, spatial characteristics such as localized populations of dead cells might adversely affect the spread of infection, similar to the manner in which a counter-fire can stop a forest fire from spreading. In order to investigate the influence of spatial heterogeneities on viral spread, a simple 2-D cellular automaton (CA) model of a viral infection has been developed. In this initial phase of the investigation, the CA model is validated against clinical immunological data for uncomplicated influenza A infections. Our results will be shown and discussed.

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Year:  2005        PMID： 15530492     DOI： 10.1016/j.jtbi.2004.08.001

Source DB:  PubMed          Journal:  J Theor Biol        ISSN： 0022-5193            Impact factor:   2.691


  43 in total

1.  Sharing the burden: antigen transport and firebreaks in immune responses.

Authors:  Andreas Handel; Andrew Yates; Sergei S Pilyugin; Rustom Antia
Journal:  J R Soc Interface       Date:  2008-08-15       Impact factor: 4.118

2.  The impact of host immune status on the within-host and population dynamics of antigenic immune escape.

Authors:  Shishi Luo; Michael Reed; Jonathan C Mattingly; Katia Koelle
Journal:  J R Soc Interface       Date:  2012-05-09       Impact factor: 4.118

3.  Dynamics of influenza virus infection and pathology.

Authors:  Roberto A Saenz; Michelle Quinlivan; Debra Elton; Shona Macrae; Anthony S Blunden; Jennifer A Mumford; Janet M Daly; Paul Digard; Ann Cullinane; Bryan T Grenfell; John W McCauley; James L N Wood; Julia R Gog
Journal:  J Virol       Date:  2010-02-03       Impact factor: 5.103

4.  A spatial model of the efficiency of T cell search in the influenza-infected lung.

Authors:  Drew Levin; Stephanie Forrest; Soumya Banerjee; Candice Clay; Judy Cannon; Melanie Moses; Frederick Koster
Journal:  J Theor Biol       Date:  2016-02-23       Impact factor: 2.691

5.  Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors.

Authors:  Hulin Wu; Arun Kumar; Hongyu Miao; Jeanne Holden-Wiltse; Timothy R Mosmann; Alexandra M Livingstone; Gabrielle T Belz; Alan S Perelson; Martin S Zand; David J Topham
Journal:  J Immunol       Date:  2011-09-23       Impact factor: 5.422

6.  Immature oxidative stress management as a unifying principle in the pathogenesis of necrotizing enterocolitis: insights from an agent-based model.

Authors:  Moses Kim; Scott Christley; John C Alverdy; Donald Liu; Gary An
Journal:  Surg Infect (Larchmt)       Date:  2012-01-04       Impact factor: 2.150

Review 7.  Solving Immunology?

Authors:  Yoram Vodovotz; Ashley Xia; Elizabeth L Read; Josep Bassaganya-Riera; David A Hafler; Eduardo Sontag; Jin Wang; John S Tsang; Judy D Day; Steven H Kleinstein; Atul J Butte; Matthew C Altman; Ross Hammond; Stuart C Sealfon
Journal:  Trends Immunol       Date:  2016-12-13       Impact factor: 16.687

8.  Agent-based modeling of host-pathogen systems: The successes and challenges.

Authors:  Amy L Bauer; Catherine A A Beauchemin; Alan S Perelson
Journal:  Inf Sci (N Y)       Date:  2009-04-29       Impact factor: 6.795

Review 9.  Viral kinetic modeling: state of the art.

Authors:  Laetitia Canini; Alan S Perelson
Journal:  J Pharmacokinet Pharmacodyn       Date:  2014-06-25       Impact factor: 2.745

10.  A cellular automaton framework for infectious disease spread simulation.

Authors:  Bernhard Pfeifer; Karl Kugler; Maria M Tejada; Christian Baumgartner; Michael Seger; Melanie Osl; Michael Netzer; Michael Handler; Andreas Dander; Manfred Wurz; Armin Graber; Bernhard Tilg
Journal:  Open Med Inform J       Date:  2008-04-24
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