| Literature DB >> 15530411 |
K Zouaoui Boudjeltia1, N Moguilevsky, I Legssyer, S Babar, M Guillaume, P Delree, M Vanhaeverbeek, D Brohee, J Ducobu, C Remacle.
Abstract
The present paradigm of atherogenesis proposes that low density lipoproteins (LDL) are trapped in subendothelial space of the vascular wall where they are oxidized. Myeloperoxidase (MPO) plays a key role in oxidative damage. We propose that LDL oxidation by myeloperoxidase (Mox-LDL) could occur at the surface of the endothelial cells and not restricted to the subendothelial space. The triad constituted by endothelial cells, circulating LDL and MPO in close interaction, constitutes a synergic mechanism for the genesis of Mox-LDL.Entities:
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Year: 2004 PMID： 15530411 DOI： 10.1016/j.bbrc.2004.10.049
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575