| Literature DB >> 15530123 |
Alan J Anderson1, Jesse M Nicholson, Oladapo Bakare, Ray J Butcher, K R Scott.
Abstract
An improved method for the synthesis of benzamides from 3-amino-2-cyclohexenones is presented. Using sodium hydride, a base-catalyzed N-benzoylation provided significantly higher yields (71-79%) for the reported compounds. This novel protocol was applied in the solution-phase parallel synthesis of a 12-member library of vinylic benzamide derivatives of 3-amino-2-cyclohexenones in 63-90% yield, using a Radley's Carousel Reaction Station.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15530123 DOI： 10.1021/cc0498837
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766