| Literature DB >> 15528445 |
Ichiro Nakagawa1, Atsuo Amano, Noboru Mizushima, Akitsugu Yamamoto, Hitomi Yamaguchi, Takahiro Kamimoto, Atsuki Nara, Junko Funao, Masanobu Nakata, Kayoko Tsuda, Shigeyuki Hamada, Tamotsu Yoshimori.
Abstract
We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.Entities:
Mesh：
Year: 2004 PMID： 15528445 DOI： 10.1126/science.1103966
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728